PLOS BiologyPam16 & Pam18 are essential for #mitochondrial protein import in eukaryotes, but not in #Trypanosomes. @aschneiderlab show that TbPam16/18 have been repurposed to regulate #replication of #maxicircles within the T. brucei mitochondrial genome #PLOSBiology https://plos.io/3STOEis
Pam16 and Pam18 were repurposed during Trypanosoma brucei evolution to regulate the replication of mitochondrial DNA
Pam16 and Pam18 are conserved co-chaperones essential for mitochondrial protein import in eukaryotes, but not in the parasite Trypanosoma brucei. This study shows that the function of TbPam16/18 has been repurposed during evolution to regulate the replication of maxicircles within the T. brucei mitochondrial genome.