After a looong journey, I can present you the results of a deep & thorough investigation of human plasma proteolysis by mass spec: SLE N-terminomics paper with a complement C3 fragment(s) is out now in EMBOJ: https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8 - highlights: a nice resource on proteolytically processed N-termini in human plasma of healthy & SLE patients, with a lot of complement bonus for all interested scientists. #SLE #Science #Proteomics #TeamMassSpec #InflammatoryDisease #LupusResearch #C3 #LHF1 1/10

Der Mann hat was neues für #Lupus gefunden - oder wie @kabalak selbst sagen würde:

In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.

#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch

https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8

Critical Reviews in Immunology (@crijournal.bsky.social)

The SLE Conundrum: A Comprehensive Analysis of Pathogenesis, Recent Developments, and the Future of Therapeutic Interventions https://www.dl.begellhouse.com/journals/2ff21abf44b19838,64a172b927050513,5663a19227f6eb0f.html #LupusResearch #Pathogenesis #PrecisionMedicine

Bluesky Social

🌟 Breakthrough in Lupus Research! 🌟
Scientists at Northwestern University have identified a cause of lupus and a potential way to reverse it. This discovery could lead to new treatments and hope for millions affected by this autoimmune disease. - https://news.feinberg.northwestern.edu/2024/07/10/scientists-discover-a-cause-of-lupus-and-a-possible-way-to-reverse-it/

#LupusResearch #AutoimmuneDisease #MedicalBreakthrough #HealthInnovation #NorthwesternUniversity #GoodNews

@goodnews

Scientists Discover a Cause of Lupus and a Possible Way to Reverse It - News Center

Scientists have discovered a molecular defect that promotes the pathologic immune response in lupus and demonstrated that reversing the defect may potentially reverse the disease.

News Center

🚨 Breakthrough Alert! 🧬 Scientists may have cracked the code on #Lupus! 🔬 Researchers announce a potential game-changer that could lead to a CURE! 🎉 This groundbreaking discovery brings hope to millions living with the autoimmune disease. 💪 #LupusResearch #MedicalBreakthrough #AutoimmuneDisease #ScienceNews

🔗 https://www.newser.com/story/352798/scientists-identify-potential-lupus-breakthrough.html

Scientists Identify Potential Lupus Breakthrough

Researchers say findings could lead to 'potential cure'

Newser LLC
Have you talked to your doctor about your vitamin D levels? A study showed nearly half of participants with lupus were vitamin D deficient. While avoiding deficiency is important, the study found short-term vitamin D supplementation did not impact disease activity. #lupusresearch

Do you want to help accelerate the development of #lupus treatments & a potential cure?

Be an advocate for your health by joining RAY, our online lupus registry where you can be an active member in the fight against lupus! Sign up today! https://bit.ly/3V2tkWk

#lupusresearch

RAY: Research Accelerated by You

Read about enrolling in the RAY: Research Accelerated by You lupus registry. The registry is for people with a diagnosis of lupus, and helps researchers better understand the disease.

Lupus Foundation of America

#esittely
#RIPTwitteristä siirtynyt peruskoulun kielenopesta 50vee alaa vaihtanut olio, buumeri, joka pohtii mitä tehdä isona. Seuraan harvinaissairauden tutkimusta toivottavasti täälläkin, se on edennyt harppauksin 10 vuoden aikana.
#Helsinki #ilmastokriisi #luontokato #ihmisoikeudet #politiikka #turpo

#introduction
Lupus Europe PAN member #Lupus #LupusResearch #SLE
#climate #ukraine #nafo #fellas