New publication: Total Synthesis, Structure Elucidation, and Bioactivity Evaluation of the Cyclic #Lipopeptide Natural Product #PaenilipoheptinA,. #bacteria #antibiotics #pharmaceuticals
https://doi.org/10.1021/acs.orglett.5c00232

Metal coordinating-induced self-assembly of cyclic lipopeptides into high-performance antimicrobial supramolecules

-in Food Chemistry

#Bacillus #lipopeptide

https://www.sciencedirect.com/science/article/abs/pii/S030881462300821X

Bacterial endosymbionts of beneficial soil fungi protect their hosts against micropredators such as fungivorous nematodes with a cytotoxic benzolactone.

We now found that the anthelminthic effect is boosted with a biosurfactant named symbiosin. Although this compound resembles some fungal metabolites, it is also produced by endofungal bacteria.

Our first paper in 2023 πŸ₯³
OA in Chemical Science
πŸ”— http://ow.ly/zBNg50LZazP
#ChemBioSys #NRPS #biosynthesis #lipopeptide #NaturalProducts #symbiosis

Endofungal bacteria boost anthelminthic host protection with the biosurfactant symbiosin

Effective protection of soil fungi from predators is crucial for their survival in the niche. Thus, fungi have developed efficient defence strategies. We discovered that soil beneficial Mortierella fungi employ a potent cytotoxin (necroxime) against fungivorous nematodes. Interestingly, this anthelminthic ag