Yvon JaillaisThis is so cool! We know that the ER basically impacts all the other organelles in the cell.
Now Volker Haucke's lab shows that endosomes feedback on the ER to shape its morphology via #lipidetime and membrane contacts. @ScienceMagazine
Distinct changes in endosomal composition promote NLRP3 inflammasome activation @NatImmunol
▶️ PI4P as a master regulator of inflammasome recruitment and activation in endosomes #lipidetime #membranecontactsites
Distinct changes in endosomal composition promote NLRP3 inflammasome activation - Nature Immunology
A dogma in the inflammasome field is that NLRP3 activation occurs at dispersed vesicles of the trans-Golgi network. Here, Ricci and colleagues find that these vesicles are of endosomal origin and that endosomes comprise the compartment where NLRP3 is activated.