Missed our early December webinar with James Olzmann? Catch it here: www.lipidmaps.org/resources/ed... The webinar offered key insights into lipid metabolism and ferroptosis. Attendees learned about the impact of lipid droplets on cellular lipid balance and ferroptosis. #LipidDroplets #Lipidomics

The December issue is online:

https://embopress.org/toc/14693178/25/12

The cover features work by Stacey Gilk identifying a novel #bacterial effector protein that mediates ER-LD #membrane contacts to regulate host #lipiddroplets.

-> https://embopress.org/doi/full/10.1038/s44319-024-00266-8

Non-alcoholic fatty liver disease induced by a high-fat diet increases the association of mitochondria with lipid droplets, which can be reversed by a treadmill running routine. 🏃

preLight from Hellen Costa & Marcus Oliveira who cover work from Juan Carlos Bórquez & team.

#preLight 👉https://prelights.biologists.com/highlights/effects-of-aerobic-exercise-in-hepatic-lipid-droplet-mitochondria-interaction-in-non-alcoholic-fatty-liver-disease-v2/

#exercise #LipidDroplets #mitochondria #NAFLD #biochemistry

Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease - preLights

Non-alcoholic fatty liver disease induced by a high-fat diet increases the association of mitochondria with lipid droplets, which can be reversed by a treadmill running routine.

preLights
How do #viruses exploit host cell #lipiddroplets for their replication?
Binbin Ding and coworkers show #SARSCoV2 ORF6 protein to bring lipid droplets in contact with ER and #mitochondria to alter cellular #lipid flux
https://www.embopress.org/doi/10.15252/embj.2022112542

Ivanovska et al. Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture. @JCellBiol

One of those findings that sounds really surprising (almost contradictory) but then makes you realise that you had no idea how rigid a lipid droplet was anyway!

https://doi.org/10.1083/jcb.202208123

#CellBiology #LipidDroplets

Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture

Ivanovska and Tobin plus coworkers show that fat-filled lipid droplets have a high interfacial tension which helps to maintain the sphericity of small droplets—

Rockefeller University Press
Our paper "ATGL promotes prostaglandin-dependent actin remodeling by regulating substrate release from lipid droplets" was accepted with minor revisions by Development!!!! #lipiddroplets #prostaglandin #Drosophila #oogenesis #actin
Thinking about lipid droplets a lot lately. So many of them here 👇 #lipiddroplets (in green) #microscopy

Are you also fascinated by #InterorganellarCommunication via #MembraneContactSites?

Check out my weekly report, summarizing the latest work on membrane contact sites.

http://biomed.news/bims-mecosi/2022-12-18

This week’s issue entails 8 publications, addressing MCS aspects in #Autophagy, #LipidDroplets, #SuperResolutionMicroscopy and more!

This is in close collaboration with #BioMedNews, a #MachineLearning platform that pre-selects potentially interesting work for me to curate and do the final assortment.

bims-mecosi 2022-12-18 papers

Active #lipids enable intelligent swimming of #microplankton under nutrient limitation https://phys.org/news/2022-11-microplankton-lipids-enable-intelligent-nutrient.html #protists #plankton #biophysics

Active reconfiguration of cytoplasmic #LipidDroplets governs migration of nutrient-limited #phytoplankton https://www.science.org/doi/10.1126/sciadv.abn6005

#Algae adopt a thrifty lifestyle when nutrients turn limiting. They strategically harness internal lipids to regulate swimming properties to maximize their fitness.

Microplankton study: Active lipids enable intelligent swimming under nutrient limitation

Biophysicists from the University of Luxembourg have uncovered how microplankton—key photosynthetic organisms which produce nearly 50% of the oxygen we breathe—adopt a thrifty lifestyle when nutrients turn limiting. They strategically harness internal lipids to regulate swimming properties to maximize their fitness.

Phys.org

That awkward moment when you automate your embryo image acquisition and end up creating modern art with stitching artifacts and also the egg isn’t fertilized so it’s not really an embryo 🫠

#lipiddroplets #microscopy #fluorescencemicroscopy #embryos #developmentalbiology #devbio #annelids