CellBioNewsJul 13, 2024

A stealth #fungus has decimated North American #bats, but scientists may be a step closer to treating #white_nose syndrome.

#epizootic #Pseudogymnoascus #infection #keratinocytes #EGFR

https://phys.org/news/2024-07-stealth-fungus-decimated-north-american.html

A stealth fungus has decimated North American bats, but scientists may be a step closer to treating white-nose syndrome

An invasive fungus that colonizes the skin of hibernating bats with deadly consequences is a stealthy invader that uses multiple strategies to slip into the small mammals' skin cells and quietly manipulate them to aid its own survival. The fungus, which causes the disease white-nose syndrome, has devastated several North American species over the last 18 years.

Phys.org
PLOS BiologyOct 20, 2023
Multiomic comparison of #LimbalStemCells (maintain the #cornea) with #keratinocytes (maintain the #skin) reveals an intriguing interplay of TFs that drive #epithelial similarities & differences in health & disease @JoHZhou_Lab @svheeringen #PLOSBiology https://plos.io/3rYksbG
Identification of the regulatory circuit governing corneal epithelial fate determination and disease

This study uses multiomics and gene regulatory network analysis to compare the limbal stem cells that maintain the cornea with keratinocytes which maintain the skin, revealing an intriguing interplay of transcription factors that drive epithelial similarities and differences in health and disease.

katch wreckAug 8, 2023

"Pharmacological YAP activation enacts a reversible pro-proliferative #transcriptional program in #keratinocytes and #dermal cells that results in accelerated re-epithelization and regranulation of the #wound bed. These results demonstrate that transient topical administration of a YAP activating agent may represent a generalizable $therapeutic approach to treating cutaneous wounds."

https://www.pnas.org/doi/abs/10.1073/pnas.2305085120

#skin #healing