I will not be at ASCB this year but if you’re going, please check out Sahil Kamboj’s @sahilkamboj poster

'Flash multiscale tuning of cell-microenvironment interactions in ovarian cancer'
Tuesday, Dec 5, from 12:15 PM
Poster 3005

Fun collaboration between @roylelab and Ambroise Lambert et al. at Paris Cergy

#CellBiology #MembraneTrafficking #cancer #integrins

Tong et al explore the conformational landscape of integrin αIIbβ3 from bent to extended states and the implication for adhesion stability.
"Integrin αIIbβ3 intermediates: From molecular dynamics to adhesion assembly"
https://doi.org/10.1016/j.bpj.2022.12.032
#Integrins #CellAdhesion
Getting more comfortable here and so it’s time for an #introduction ?
I never planned on doing a PhD and certainly not on staying afterwards. But somehow I got hooked on #microscopy and #celladhesion and especially #integrins , more recently also #TGF s. So I stopped my high school teacher career and here I am… And if research also doesn’t work out I might pursue a career in integrin-themed cakes
Biering, S.B., Gomes de Sousa, F.T., Tjang, L.V. et al. #SARS-CoV-2 #Spike triggers barrier dysfunction and #vascular leak via #integrins and #TGF-β signaling. Nat Commun 13, 7630 (2022). https://doi.org/10.1038/s41467-022-34910-5

#introduction:
We are a new cell systems biology team at the #UniversityOfManchester #UoM.
We study #CellAdhesion #networks in health and disease, especially #cancer.
Fascinated by how adhesion proteins help #cells function in so many ways!

#proteomics #integrins #adhesion #cytoskeleton #nucleus #bioinformatics #omics #ExtracellularMatrix #ECM #NetworkBiology #DataViz