Show threadStephan HackerMay 9
Congratulations to @[email protected] and all others involved at @[email protected], Arvinas and Pfizer. #InducedProximity should be at the top of many The Nobel Prize lists now. #TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success #ChemSky #ChemBio
Show threadStephan HackerMay 9
Many additional exciting applications of #InducedProximity have already been shown in basic academic research (#PROTAC, #RIPTAC, #LYTAC, #AUTEC, #RIBOTAC, #PhosTAC, #PHICS, #OGTAC, #ACETAC, #ACETAG, #DUBTAC). Curious, which other therapeutic areas will most profit from this development. (2/3)
Show threadStephan HackerMay 9

Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)

#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success

Stephan HackerDec 10
Interesting bioRxiv preprint by the groups of Liron Bar-Peled and A. John Iafrate. They introduce COUPLrs - structurally diverse molecules with 2 electrophilic warheads and an alkyne - to identify proteins that can be linked to other proteins. https://www.biorxiv.org/content/10.1101/2024.07.16.603666v1
#Chemistry #ChemBio #ChemPro #InducedProximity
Stephan HackerNov 25

Great talk by Nathanael Gray at #ISCPDD. He presented his group’s work on induced proximity to regulate transcription. Exciting data on recruiting a transcriptional activator (e.g. BRD4 or CDK9) to replace co-repressors on the death regulator BCL6 to induce cell death.

https://www.nature.com/articles/s41586-023-06348-2
#Chemistry #ChemBio #InducedProximity

Rewiring cancer drivers to activate apoptosis - Nature

A new class of molecules can recruit downstream transcription factors or endogenous cancer drivers to cell death promoters and activate the expression of these genes.

Nature
jobRxivJan 12, 2025

Chemical Biology Postdoc in the Ferguson Lab at UCSD

University of California, San Diego

Join our team working on #TPD #InducedProximity as a Postdoctoral fellow in the Ferguson lab at UCSD

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=91...
https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=91018

Chemical Biology Postdoc in the Ferguson Lab at UCSD

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv
jobRxivJan 8, 2025

Chemical Biology Postdoc in the Ferguson Lab at UCSD

University of California, San Diego

Join our team working on #TPD #InducedProximity as a Postdoctoral fellow in the Ferguson lab at UCSD

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=90...
https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=90738

Chemical Biology Postdoc in the Ferguson Lab at UCSD

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv
Adam M GilbertJan 31, 2023
An affinity-directed phosphatase (AdPhosphatase) system for targeted dephosphorylation of specific phospho-substrates - a useful tool as we start to build PHORC/PHIC induced proximity modulators #inducedproximity #PFEColleague https://bit.ly/3Hl9Kj5
Adam M GilbertJan 24, 2023
Local Cysteine Capture (Cys-LoC), and Local Cysteine Oxidation (Cys-LOx) methods can define the subcellular cysteinome and inflammation-responsive mitochondrial redoxome #inducedproximity #PFEColleague https://bit.ly/3WAjyew
Show threadRyan Potts, Ph.D.Jan 13, 2023
These analysis should help the field when thinking about how to identify degrading and non-degrading molecular glues in a prospective way. Thank you to co-authors Huan Rui, Jaeki Min, Kate Ashton, and Connie Wang. #TPD #GLUEs #InducedProximity