Mastodawn

Technische Universität München Jul 11, 2024

New research reveals that cells in blood vessels in the #liver start a "sleep timer" that switches off #ImmuneCells in #ChronicHepatitisB. Targeting this mechanism could be a starting point for new #immunotherapies: http://go.tum.de/857974

📷A. Heddergott

"Sleep timer" for immune cells discovered

In chronic hepatitis B, a "sleep timer" is triggered in immune cells, which switches them off. This prevents them from destroying infected liver cells.

David Basanta Gutierrez Apr 1, 2024

Special #seminar this Thursday, 4/4, at noon EST with Jason George from Texas A&M. Dr. George will discuss #biophysical and stochastic modeling of the tumor-immune interaction for optimizing T cell #immunotherapies. And you can join here:

https://moffitt.zoom.us/j/91265406655

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Scientific Frontline Dec 20, 2023

Despite their promise, #immunotherapies fail to treat many #cancers, including over 80% of some of the most advanced #breast cancers. And many of those patients who do respond still experience #metastases eventually.
#Biology #Chemistry #Medical #Pharmaceutical #sflorg
https://www.sflorg.com/2023/12/bio12202304.html

Researchers uncover on/off switch for breast cancer metastasis

A new and more effective immunotherapy and help clinicians better predict patient response to existing medicines.

Scientific Frontline Oct 7, 2023

A molecule made by #Streptococcus #pyogenes — the #bacterium that causes #strep throat — could help explain the origins of enigmatic #autoimmune diseases such as #rheumatic fever and #lupus. Findings illuminate why century-old #cancer #immunotherapies showed promise and why modern immune therapies for cancer don’t work as often as they could.
#Biology #Chemistry #Medical #Microbiology #sflorg
https://www.sflorg.com/2023/10/bio10072301.html

Strep Molecule Illuminates Cancer Immune Therapies

Insights could help scientists manipulate the immune system to treat cancer or certain autoimmune diseases.

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Wout Bittremieux Jul 21, 2023

We validated the identified immunopeptides based on known HLA motifs, as well as predicted binding affinity using NetMHCpan.

In conclusion, our timsTOF fragment ion intensity prediction model can be used for PSM rescoring to highly accurately and sensitively identify immunopeptides. This has several important implications for the discovery of (neo-)epitopes and development of #immunotherapies.

For more detailed information, check out the preprint! https://www.biorxiv.org/content/10.1101/2023.07.17.549401v1

Scientific Frontline Mar 30, 2023

An international team including scientists from the UNIGE and Harvard has discovered a new type of #immune #cell whose action is essential for the success of #immunotherapies.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/03/med03302301.html

Allies or enemies of cancer: the dual fate of neutrophils

A new type of immune cell whose action is essential for the success of immunotherapies.

Carolyn King Feb 8, 2023

RT from the fabulous Ana Correia @alpcorreia

Thrilled to share my Perspective on how #TissueImmunity selectively restrains the growth of metastases - an exciting avenue for developing #Immunotherapies for long-lasting control of #Metastasis
Thanks Lucy Bird and @NatRevImmunol for the opportunity!
👉rdcu.be/c4539

Scientific Frontline Feb 5, 2023

#Scientists at St. Jude Children’s Research Hospital added a #molecular anchor to #chimeric #antigen #receptors (#CARs), increasing the anti-cancer activity of cellular #immunotherapies in #cancer models.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/02/bio02052305.html

St. Jude scientists create more efficient CAR immunotherapies using a molecular anchor

CAR immunotherapies using a molecular anchor

Scientific Frontline Feb 2, 2023

A research group at the University of Basel has identified a #gene that drives T #lymphocytes (#Tcell) to exhaustion. This finding opens up new approaches for more effective #immunotherapies.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/02/bio02022301.html