Allen Tien, MD, MHS mdlogix.com 94,698 田一彦
KiwiNikkiJust been to the mall here in #OtautahiChristchurch and heard what sounds like a little one with whooping cough. So I guess we got that here now too. Poor kiddo. #CovidNZ #immunedamage
datum (n=1)In preprint still, but the abstract concludes: "protection wanes rapidly and is entirely lost one year after the previous infection. The findings support considerable immune evasion by JN.1"
Actually it's WORSE than that. Average protection was -2.5% a year after infection, though error bars include 0.
In other words, a year after infection, evidence indicates immune damage outweighs residual immunity.
Did you catch that?
** A year after infection, immune damage outweighs residual immunity! **
And even at 9 months, a significant proportion of people were MUCH more likely to get reinfected - the error range descends down past -30%!
That means 9 months after infection, for some people, they are 1.5x more likely to get another #SARS2 infection!
https://www.medrxiv.org/content/10.1101/2024.02.22.24303193v1
#ImmuneDamage
#stillCOVIDing
#CovidIsNotOver #covid19
#HybridImmunityIsFantasy
Protection of natural infection against reinfection with SARS-CoV-2 JN.1 variant
This study investigated the effectiveness of natural infection in preventing reinfection with the JN.1 variant during a large JN.1 wave in Qatar, using a test-negative case-control study design. The overall effectiveness of previous infection in preventing reinfection with JN.1 was estimated at only 1.8% (95% CI: −9.3-12.6%). This effectiveness demonstrated a rapid decline over time since the previous infection, decreasing from 82.4% (95% CI: 40.9-94.7%) within 3 to less than 6 months after the previous infection to 50.9% (95% CI: −11.8-78.7%) in the subsequent 3 months, and further dropping to 18.3% (95% CI: −34.6-56.3%) in the subsequent 3 months. Ultimately, it reached a negligible level after one year. The findings show that the protection of natural infection against reinfection with JN.1 is strong only among those who were infected within the last 6 months, with variants such as XBB*. However, this protection wanes rapidly and is entirely lost one year after the previous infection. The findings support considerable immune evasion by JN.1. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement The authors are grateful for support from the Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research Core at Weill Cornell Medicine in Qatar; the Qatar Ministry of Public Health; Hamad Medical Corporation; and Sidra Medicine. The authors are also grateful for the Qatar Genome Programme and Qatar University Biomedical Research Center for institutional support for the reagents needed for the viral genome sequencing. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The institutional review boards at Hamad Medical Corporation and Weill Cornell Medicine in Qatar approved this retrospective study with a waiver of informed consent. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as [ClinicalTrials.gov][1]. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes The dataset of this study is a property of the Qatar Ministry of Public Health that was provided to the researchers through a restricted access agreement that prevents sharing the dataset with a third party or publicly. Future access to this dataset can be considered through a direct application for data access to Her Excellency the Minister of Public Health ([https://www.moph.gov.qa/english/Pages/default.aspx][2]). Aggregate data are available within the manuscript and its Supplementary information. [1]: http://ClinicalTrials.gov [2]: https://www.moph.gov.qa/english/Pages/default.aspx3
Kiki BuberLike, this time a year ago increased strep was put down to kids having had 18 months of not breathing on each others’ faces. So this year things should be better, right? Oh what’s this I’m hearing? 300% – 400% worse?? #Covid19 #CovidIsntOver #immunedamage
Today in insane denial of COVID's harm to the immune system, the CDC speculates that one reason Candida has exploded 10x since its pre-pandemic rate is because, due to COVID causing us to be super careful about aerosols, we have gotten careless about environmental disinfection. Can't make this shit up. #covid #immunedamage https://arstechnica.com/science/2023/03/deadly-drug-resistant-yeast-gained-ground-more-drug-resistance-amid-covid/
Geoff BoydGreat thread on #immunedamage from #SarsCoV2 complete with links. By @jeffgilchrist
https://pingthread.com/thread/1605958004163084292
https://pingthread.com/thread/1605958004163084292
Thread by jeffgilchrist: What is going on with our immune cells after COVID... - PingThread
What is going on with our immune cells after COVID-19 infection? This thread will explore some of the impacts of COVID infection on our immune system even after people are recovered including: - Missing naive T-cells - Exhausted T-cells - Loss of B-cell maturation 🧵1/
Lorrainehttps://nitter.net/dfisman/status/1603854850311061504?s=46&t=7s42W1Svlm7N5DwtH0Wo2w h/t @Delilahsitting
took me a minute to understand this & the implications..but after I got some sleep..
#nocardiosis #ImmuneDamage #wearTheDamnMask #HEPA #COVIDisAirborne #FFS #bacteria #WeAreAllVulnerable #NoCovid #zeroCovid @NjbBari3 @dfisman @DSlayer520
took me a minute to understand this & the implications..but after I got some sleep..
#nocardiosis #ImmuneDamage #wearTheDamnMask #HEPA #COVIDisAirborne #FFS #bacteria #WeAreAllVulnerable #NoCovid #zeroCovid @NjbBari3 @dfisman @DSlayer520
Haplogroup News 
Strep A child death toll in UK rises to 15 | Guardian
Data shows 13 under-15s in England, one in Northern Ireland and one in Wales have died since Septemberhttps://www.theguardian.com/society/2022/dec/08/strep-a-child-death-toll-in-uk-rises-to-15 #StrepA #ImmuneDamage #UnitedKingdom #SARS2
Alison#ImmunityDebt is not how the #ImmuneSystem works. The phrase "we're all getting sick now because we isolated/#lockdown" is widely circulating. It is not true. However, it is entirely possible that every other germ is proliferating because #Covid19 is known to cause #ImmuneDamage don't be sucked in. We knew this could happen. We knew, and preferred protecting our vacuous lifestyles than protect each other. #WearAMask #N95OrBetter #COVIDisAirborne
MutterundKind geimpftKönnte das so sein?
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RT @C_atlm
Die "#KITA-Studie" kommt zeitlich passend vor der anstehenden Welle mit stärker immunflüchtigen Varianten.
Ein politischer Schachzug, um #Eltern @bundeseltern friedlich auf massive "all mild, passiert nichts, war nie schlimm" Infektionen für den Winter einzustimmen?
#ImmuneDamage
https://twitter.com/C_atlm/status/1587967491170598914
C_atlm on Twitter
“Die "#KITA-Studie" kommt zeitlich passend vor der anstehenden Welle mit stärker immunflüchtigen Varianten. Ein politischer Schachzug, um #Eltern @bundeseltern friedlich auf massive "all mild, passiert nichts, war nie schlimm" Infektionen für den Winter einzustimmen? #ImmuneDamage”