Some executioner caspases also have non-apoptotic functions. This study shows that sublethal executioner
#caspase activation enhances
#hepatocyte proliferation via JAK/STAT3 signaling, revealing a role for executioner caspases in promoting liver
#regeneration @PLOSBiology https://plos.io/3JEsH57Analysis of the effect of
#hepatocyte p110α deletion on metabolic homeostasis in mice reveals that PI3Kα signaling is critical for the regulation of
#liver gene expression and its reprogramming in the context of
#HepaticSteatosis @PLOSBiology https://plos.io/4jGLBoD
Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling
The metabolic effects of insulin depend on the PI3K pathway. This study analyzes the effect of hepatocyte p110α deletion on metabolic homeostasis in mice and shows that PI3Kα signaling is critical for the regulation of liver gene expression and its reprogramming in the context of hepatic steatosis.
PLOS Biology
