Directed molecular evolution of muscarinic receptors

📉 Evolved GPCRs activated by CNO, not acetylcholine
🧪 CNO activates M3 with 20-30 nM potency
🔬 hM4D receptor induces neuronal silencing for mtd
#GCPR #CNO #DREADD #hM3D #hM4D #molecularEvolution

https://dev.https://tnyp.me/CcS0q4hQ/m