Animalogic put out an interesting Floralogic episode on the extreme, long-lasting pain caused by gympie gympie - a plant in the same family as stinging nettle -

Gympie Gympie Is Doing Everything It Can To Ruin Your Life
https://youtu.be/kIGQYE8pH_Y?si=4QN-DzBHdRg3OEen

It's an Australian plant, of course.

"Altering the activation threshold, combined with effects upon inactivation, likely leads to nociceptor activation and the sensation of pain, akin to biophysical changes observed in painful conditions associated with NaV1.7 [SCN9A] gain-of-function mutations such as inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD), respectively ... As the gympietides bear little similarity to any other known NaV modulators and display unusual effects particularly on NaV inactivation, it is difficult to predict possible binding sites at this point. However, based on activity of animal venom–derived toxins and the biophysics of NaV gating, the extracellular loops of the domain IV voltage sensor could be a possible binding site."
https://doi.org/10.1126/sciadv.abb8828

#Pain #nociception #NaturalProducts #erythromelalgia #gympietides #SodiumChannels #SCN9A