U01.01.123 Glycogen Regulation: Insulin, Glucagon, and Epinephrine

Master the hormonal control of glycogen metabolism. Learn how Insulin, Glucagon, and Epinephrine regulate Glycogen Synthase and Glycogen Phosphorylase via phosphorylation states. High-yield USMLE Step 1 biochemistry on mymedschool.org.

mymedschool.org
U01.01.097 Fructose-2,6-bisphosphate: The Master Switch of Glycolysis and Gluconeogenesis

Master the pivotal role of Fructose-2,6-bisphosphate (F-2,6-BP) in metabolic regulation with our U01.01.097 guide. Learn how the PFK-2/FBPase-2 bifunctional enzyme complex responds to Insulin and Glucagon to toggle between energy production and glucose synthesis. Essential biochemistry for USMLE Step 1 prep on mymedschool.org.

mymedschool.org
U01.01.096 Glycolysis Regulation: PFK-1, Pyruvate Kinase & Hormonal Control

Master the complex regulation of Glycolysis with our U01.01.096 guide. Explore the three irreversible steps, the pivotal role of PFK-1, and how Fructose-2,6-bisphosphate acts as the master metabolic switch. Understand the hormonal influence of Insulin and Glucagon on enzyme phosphorylation. Essential preparation for USMLE Step 1 on mymedschool.org.

mymedschool.org
A New "Tetra-Functional" Weight Loss Drug from Tufts Reduces Weight as Well As Bariatric Surgery. #obesity #semaglutide #tirzepatide #diet #glp1 #gip #glucagon #pyy
https://www.instagram.com/p/DMYbs7tJz7Q/
Howard G. Smith MD, AM on Instagram: "New Weight Loss Drug Mimics More Gut Hormones A new so-called “tetra-functional” diet compound has added power and its effects match the weight loss result of bariatric surgery. Chemists at Boston’s Tufts University have engineered a next-generation compound that mimics the action of four different gut hormones involved in appetite control, metabolism, and energy use. They are GLP-1, GIP, glucagon, and the uncommonly mimicked PYY. This novel chimeric peptide could deliver up to 30% body weight loss. That effect exceeds the effects of our current crop of weight loss drugs semaglutide and tirzepatide, marketed as Ozempic, Wegovy, and Mounjaro. Semaglutide mimics only GLP1 while tirzepatide mimics both GLP1 and GIP. This compound is newly discovered and not yet ready for clinical application. When it is, this powerful agent will be an invaluable help for those suffering from excess weight and weight-induced health problems including diabetes, heart disease, and cancer. The hope is that it will quickly move from the laboratory bench into preclinical and clinical trials…..someday soon. https://www.sciencedaily.com/releases/2025/06/250612081323.htm https://pubs.acs.org/doi/10.1021/jacs.5c04095 #obesity #semaglutide #tirzepatide #diet #glp1 #gip #glucagon #pyy"

0 likes, 0 comments - drhowardsmithreports on July 21, 2025: "New Weight Loss Drug Mimics More Gut Hormones A new so-called “tetra-functional” diet compound has added power and its effects match the weight loss result of bariatric surgery. Chemists at Boston’s Tufts University have engineered a next-generation compound that mimics the action of four different gut hormones involved in appetite control, metabolism, and energy use. They are GLP-1, GIP, glucagon, and the uncommonly mimicked PYY. This novel chimeric peptide could deliver up to 30% body weight loss. That effect exceeds the effects of our current crop of weight loss drugs semaglutide and tirzepatide, marketed as Ozempic, Wegovy, and Mounjaro. Semaglutide mimics only GLP1 while tirzepatide mimics both GLP1 and GIP. This compound is newly discovered and not yet ready for clinical application. When it is, this powerful agent will be an invaluable help for those suffering from excess weight and weight-induced health problems including diabetes, heart disease, and cancer. The hope is that it will quickly move from the laboratory bench into preclinical and clinical trials…..someday soon. https://www.sciencedaily.com/releases/2025/06/250612081323.htm https://pubs.acs.org/doi/10.1021/jacs.5c04095 #obesity #semaglutide #tirzepatide #diet #glp1 #gip #glucagon #pyy".

Instagram
How GLP-1s Are Breaking Life Insurance

Patients look healthy on paper. Two years later, they're high-risk again.

GLP-1 Digest

Got some chapstick holders that reviewers noted were great for carrying Baqsimi. Wasn’t a fan of the plastic hook so I cut that off and attached a split ring and metal carabiner hook.

https://a.co/d/4wnhw2Q

#Diabetes #Baqsimi #Glucagon #EmergencyMedicine

GLP1-RAs in Type 1 Diabetes: more than meets the eye?
Some people will be aware, and some not, that there is a reasonable minority of people with Type 1 Diabetes using GLP-1 Receptor Agonists (GLP1-RAs) such as WeGovy and Mounjaro, especially in the USA.

They are used for a couple of reasons. Often as an antidote to deal
https://www.diabettech.com/glp1-ra/glp-1s-in-type-1-diabetes-more-than-meets-the-eye/
#GLP1RA #GLP1RA #glucagon #Levicure #Mounjaro #RogerUnger #Type1Diabetes #WeGovy

GLP1-RAs in Type 1 Diabetes: more than meets the eye? | Diabettech - Diabetes and Technology

Some people will be aware, and some not, that there is a reasonable minority of people with Type 1 Diabetes using GLP-1 Receptor Agonists (GLP1-RAs) such as WeGovy and Mounjaro, especially in the USA. They are used for a couple of reasons. Often as an antidote to dealing with double diabetes and to aid weight

Diabettech - Diabetes and Technology | Where Diabetes and Technology meet
Scientists hail ‘smart’ insulin that responds to changing blood sugar levels in real time

Exclusive: People with type 1 diabetes may in future only need to give themselves insulin once a week, say experts

The Guardian
Glucagon receptor structures uncover new arrestin interaction mechanism

G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arrestins, leading to distinct physiological functions. The arrestins play critical roles in modulating GPCR functionalities by terminating G protein signaling and promoting internalization.

Phys.org