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We know about #serotonergic signaling in neurons, but what does it do in #GlialCells? This study shows that glial serotonergic signaling is important for experience-dependent #synapse elimination & targeting during #Drosophila development #PLOSBiology https://plos.io/3zJnDrG
Experience-dependent serotonergic signaling in glia regulates targeted synapse elimination

Neuronal serotonergic signaling is involved in many brain functions, but we know little about its function in glial cells. This study shows that glial serotonergic signaling is important for experience-dependent synapse elimination and targeting during development in Drosophila.

Scientists identify a key driver of myelin repair

New research from scientists at the Wu Tsai Neurosciences Institute at Stanford University has identified a key driver of myelination, the formation of protective fatty sheaths around nerve fibers.

Medical Xpress
A #SingleCellAtlas of #Drosophila #GlialCells reveals that glial morphological diversity exceeds transcriptional diversity, begging the question of how #glia acquire their diverse shapes @fernandesflylab @SD_Ackerman &co #PLOSBiology https://plos.io/3s4wAb8
A Drosophila glial cell atlas reveals a mismatch between transcriptional and morphological diversity

Both neurons and glia exhibit morphological diversity, and for neurons, transcriptional and morphological diversity correlate well with each other. This study generates a Drosophila single cell atlas of glial cells, revealing that glial morphological diversity exceeds transcriptional diversity, and begging the question of how glia acquire their diverse shapes.

Spontaneous activity is an important attribute of neurodevelopment. @cssmity &co show that satellite #GlialCells in the #PNS display isolated spontaneous Ca2+ transients, sensitive to #mechanosensitive protein #Piezo1, revealing a role for #mechanobiology in the activity of developing neural cells #PLOSBiology https://plos.io/3t0Ko6w
Piezo1-mediated spontaneous calcium transients in satellite glia impact dorsal root ganglia development

Spontaneous activity is an important attribute of neurodevelopment. This study shows that satellite glial cells in the peripheral nervous system display isolated spontaneous Ca2+ transients that are specifically sensitive to the mechanosensitive protein Piezo1, revealing a role for mechanobiology in the activity of developing neural cells.

Mapping tool reveals microglia’s shape-shifting secrets | Spectrum | Autism Research News

The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.

Spectrum | Autism Research News
Multi-omics study captures CNTNAP2’s far-ranging effects | Spectrum | Autism Research News

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

Spectrum | Autism Research News
Who works side by side with neurons to make the brain work

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