🧬 Antisense & RNAi Therapeutics: Revolutionizing Precision Medicine 🧬
The global Antisense & RNAi therapeutics market is transforming the healthcare landscape by offering targeted gene-silencing treatments for genetic disorders, cancer, and neurodegenerative diseases.
🔹 #RNAiTherapeutics #AntisenseTherapy #GeneSilencing #PrecisionMedicine #BiotechInnovation #GeneticMedicine
PTGS is dispensable for the initiation of epigenetic silencing of an active transposon in Arabidopsis.
#Transposons #TEs #EVADE #GeneSilencing #Epigenetics #TGS #PTGS #Arabidopsis
https://www.embopress.org/doi/epdf/10.1038/s44319-024-00304-5
'Phosphatidylinositol-phospholipase C3 negatively regulates the #hypersensitive response via complex signaling with #MAPkinase, #phytohormones, and reactive oxygen species in Nicotiana benthamiana'
https://doi.org/10.1093/jxb/erad184
#JasmonicAcid #ROS #SalicylicAcid #GeneSilencing #Phospholipid
In Nicotiana benthamiana, PLC3-1 and -2 complement each other during the hypersensitive response to negatively regulate and fine tune the response through sever
Gene silencing, while highly useful, has limitations in how specific it can work. Meanwhile, DNA enzymes (DNAzymes) are so accurate they can pick out incorrect alleles in RNA sequences.
But the usage of these is curtailed by their low activity due to needing high environmental magnesium.
Now, researchers have developed a targeted DNAzyme without this problem, able to target disease-causing genes.
#DNA #RNA #Medicine #Enzymes #DNAzymes #GeneSilencing #Science #Scicomm
Low activity currently prevents the wider use of DNA enzymes (DNAzymes). Here the authors report the chemical evolution of a DNAzyme with high catalytic activity under near physiological conditions: the enzyme achieves ~65 turnovers in 30 minutes.
Referenced link: https://phys.org/news/2023-05-scientists-gene-silencing-dna-enzyme.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-05-scientists-gene-silencing-dna-enzyme.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1655668260354793490#m
Scientists develop #genesilencing DNA enzyme that can target a single molecule @NatureComms https://www.nature.com/articles/s41467-023-38100-9 https://phys.org/news/2023-05-scientists-gene-silencing-dna-enzyme.html
Researchers from the University of California, Irvine have developed a DNA enzyme—or DNAzyme—that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough "gene silencing" technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.
Material & Chemical
Amelia Cervera 🧬
Journal of Experimental Botany
Sterling Ericsson
Phys.org