I am not anti-science, but I do worry about GLP-1s. Styled as a kind of miracle cure for obesity, they just haven't been around long enough for us to see the long-term effects. This article is not reassuring.

"GLP-1s may also be reshaping parts of the brain.

"Tens of millions of people are now taking the medications worldwide, turning what began as an obesity and diabetes treatment into what could be modern medicine's largest unplanned neuroscience experiments.

...

"But not all of the reported mental effects of GLP-1 drugs have been positive. On social media and at doctor's offices, some users have reported a type of brain fog and others something broader and harder to define: a strange emotional flattening. People describe less pleasure, less motivation, diminished interest in hobbies and even reduced sexual desire.

"Those accounts are beginning to raise deeper questions about what, exactly, these drugs are changing. If GLP-1s alter the brain systems involved in reward, craving and motivation, researchers wonder, where is the line between quieting a person's destructive impulses and reshaping personality itself?"

https://www.yahoo.com/news/science/articles/ozempic-may-be-reshaping-the-brain-scientists-say-155708563.html

#glp1 #ozempic

Ozempic may be reshaping the brain, scientists say

Ozempic was supposed to be a gut story. Then Allison Shapiro looked at the brain scans. An assistant professor at the University of Colorado Anschutz, she...

Yahoo News
What to Eat at Social Events While Taking GLP-1 Medications

Going to an event or party on GLP-1? Learn what to eat at social events, how to manage portions, and stay confident without restriction.

MyFitnessPal Blog
New studies find positive side effects of GLP-1 drugs used against diabetes and for weight loss. Patients taking the drugs have a lower risk of brain, kidney, heart, and liver diseases. Women taking the drugs have a 30 percent lower risk of developing breast cancer. More studies are planned. See http://www.neat-news.com/3608.php. #GLP1 #disease #cancer
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Neat News - Daily (not weekends) news about some positive development or insight.

AI 分析 41 萬 Reddit 帖文 揭減肥針潛在未知副作用
美國賓夕法尼亞大學研究人員利用 AI 分析 Reddit 逾 41 萬條帖文,發現 GLP-1 受體激動劑(包 […]
#人工智能 #健康 #社交網絡 #AI
https://unwire.hk/2026/06/05/openai-reddit-glp1-weight-loss-side-effects/life-tech/health/?utm_source=rss&utm_medium=rss&utm_campaign=openai-reddit-glp1-weight-loss-side-effects
Why Those Taking Weight Loss Pills Stop Losing Weight. The reason is in your brain cells. References on my website. #Ozempic #Wegovy #WeightLossResearch #GLP1 #HealthyAging
https://www.instagram.com/p/DZLLmxzpLFP/
Howard G. Smith MD, AM on Instagram: "Why Those Taking Weight Loss Pills Stop Losing Weight You’re getting those weight loss shots. You’re delighted as you lose weight for months. Then those scale numbers suddenly stops moving in the right direction. Why? NIH endocrinologists now show that the answer appears to be hiding inside your brain cells. They find that semaglutide, the active ingredient in Ozempic and Wegovy, triggers variable responses in appetite-controlling brain cells. That seems to be why some people lose more weight than others and why weight loss often plateaus over time. Their studies of brain tissue in mice show that semaglutide boosts a signaling molecule called cAMP inside neurons that helps regulate your appetite. But not all brain cells respond the same way. Some maintain the signal for longer periods, while others appeared to shut down their responses more quickly. When they do, the appetite-suppressing effects weaken and contribute to the weight-loss plateau that many patients experience. This finding suggests a possible way to prolong the drug’s effects. By blocking an enzyme called PDE4 with a medication known as roflumilast, the investigators were able to extend the cAMP signal in more neurons. While this finding was observed only in mice and has not been confirmed in people, it raises the possibility that future treatments could help you continue losing weight and maintain that ideal weight for longer periods of time. The references for this report are available on my website. #Ozempic #Wegovy #WeightLossResearch #GLP1 #HealthyAging"

0 likes, 0 comments - drhowardsmithreports on June 4, 2026: "Why Those Taking Weight Loss Pills Stop Losing Weight You’re getting those weight loss shots. You’re delighted as you lose weight for months. Then those scale numbers suddenly stops moving in the right direction. Why? NIH endocrinologists now show that the answer appears to be hiding inside your brain cells. They find that semaglutide, the active ingredient in Ozempic and Wegovy, triggers variable responses in appetite-controlling brain cells. That seems to be why some people lose more weight than others and why weight loss often plateaus over time. Their studies of brain tissue in mice show that semaglutide boosts a signaling molecule called cAMP inside neurons that helps regulate your appetite. But not all brain cells respond the same way. Some maintain the signal for longer periods, while others appeared to shut down their responses more quickly. When they do, the appetite-suppressing effects weaken and contribute to the weight-loss plateau that many patients experience. This finding suggests a possible way to prolong the drug’s effects. By blocking an enzyme called PDE4 with a medication known as roflumilast, the investigators were able to extend the cAMP signal in more neurons. While this finding was observed only in mice and has not been confirmed in people, it raises the possibility that future treatments could help you continue losing weight and maintain that ideal weight for longer periods of time. The references for this report are available on my website. #Ozempic #Wegovy #WeightLossResearch #GLP1 #HealthyAging".

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What to Eat at Social Events While Taking GLP-1 Medications

Going to an event or party on GLP-1? Learn what to eat at social events, how to manage portions, and stay confident without restriction.

MyFitnessPal Blog

🆕Samsung wykorzysta Galaxy Watch do ważnych badań! Smartwatche sprawdzą wpływ popularnych leków na organizm
➡️https://rootblog.pl/galaxy-watch-8-bedzie-wykorzystany-do-waznych-badan/

#GalaxyWatch #GalaxyWatch8 #GLP1 #samsung #SamsungGalaxyWatch

Weight Loss on GLP-1 Drugs Linked to Lower Risk of Disease, Study Finds. Via @sciencealert #Health ❤️‍🩹 🧑‍⚕️ #Fitness 🏃🏅🏆 #Ozempic #GLP1

Weight Loss on GLP-1 Drugs Lin...
Weight Loss on GLP-1 Drugs Linked to Lower Risk of Disease, Study Finds

Does losing weight by taking GLP-1 drugs such as Ozempic and Wegovy actually improve your risk of other diseases associated with obesity? New research led by scientists at the University of Liverpool in the UK, and presented at the European Congress on Obesity (ECO 2026), could have an answer.

ScienceAlert
One Weight Loss Strategy Is 5x More Effective Than Ozempic, Study Shows. Via @sciencealert #Health ❤️‍🩹 🧑‍⚕️ #Fitness 🏃🏅🏆 #Ozempic #GLP1

One Weight Loss Strategy Is 5x...
One Weight Loss Strategy Is 5x More Effective Than Ozempic, Study Shows

Ozempic and other semaglutide medications have been working wonders in terms of shedding pounds for many people.

ScienceAlert

Ozempic may be reshaping the brain, scientists say

https://www.yahoo.com/news/science/articles/ozempic-may-be-reshaping-the-brain-scientists-say-155708563.html?guccounter=1

> Ozempic was supposed to be a gut story. Then Allison Shapiro looked at the brain scans. An assistant professor at the University of Colorado Anschutz, she was part of a team studying 13 teens and youn...

#Ozempic #GLP1

Ozempic may be reshaping the brain, scientists say

Ozempic was supposed to be a gut story. Then Allison Shapiro looked at the brain scans. An assistant professor at the University of Colorado Anschutz, she...

Yahoo News