Benjamin S-B Aug 15

Very proud of our latest #paper out today in @sciencemagazine where we show that platelets capture cell-free DNA from their surrounding!

This was a project initiated and driven by Bethan Psaila here in Oxford. My team performed #genomics analyses to show that platelet-derived #cfDNA resembles plasma cfDNA in terms of #fragmentomics, #epigenetics and mutation patterns.

Read the paper here: https://www.science.org/doi/10.1126/science.adp3971

Or check out the summary by no other than Dennis Lo 😱:
https://www.science.org/doi/10.1126/science.aea0555

eLifeDec 7, 2023
This #ReviewedPreprint develops a framework for early #cancer detection with noninvasive methods using #methylomics and #fragmentomics. #Genetics https://elifesciences.org/reviewed-preprints/89083?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

Taylor Sundby, MD đŸ§ŦNov 16, 2022
Obligatory introductory post to find my people! I am an early stage #physicianscientist & #franciscollinsscholar in the #POB at the #NCI #NIH. My research uses #bioinformatics to integrate multi-#omics (#genomics #epigenetics #fragmentomics and #proteomics) primarily in #cfDNA #liquidbiopsy. Goal is to identify and validate #biomarkers in #rarediseases and #cancerpredispositions (focus on #NF1) with translation to the clinic and preclinical platforms (#pdx). Proponent of #openscience.