Submission deadline ๐
July 31, 2024
There is still time to submit to thematic issue โ#Organofluorine chemistry VIโ edited by David O'Hagan, University of St Andrews, in the #DiamondOpenAccess ๐๐ #BJOC.
๐ https://www.beilstein-journals.org/bjoc/series/128/?M=y
An Enantioselective Biocatalytic CโH Fluorination
Directed evolution used to create a fluorinating enzyme
https://www.chemistryviews.org/an-enantioselective-biocatalytic-c-h-fluorination/
#chemistry #chemistryviews #chemiverse #research #directedevolution #biocatalysis #fluorination
#Radiochemistry: #OpenSource flow setup for rapid & efficient [18F]fluoride drying for #automation of #PET #tracer syntheses:
-several advantages over traditional azeotropic distillation
https://doi.org/10.1002/jlcr.4080
#DIYbio #chemistry #lab #instruments #FlowChemistry #fluorination
In this work, we introduce a low-cost open-source flow system that includes a dual syringe pump with implemented pressure sensor and back pressure regulator. The entire system can be built for around 500 โฌ. Commercially available flow systems can be very expensive with equipment starting at, but often greatly exceeding, 10,000 โฌ. This high price of entry makes such technology prohibitively expensive for many research groups. Such systems stand to benefit the emerging academic pharmaceutical field by providing the experience and availability of reliable and affordable solutions. To implement accessible flow chemistry at research facilities, the systems must be made affordable. In addition, space in research laboratories is usually limited and commercially available flow systems can be very bulky. Having a compact and individually adjustable system is thus beneficial, with 3D printing technology offering the solution. Our compact 3D-printed system meets the needs of many applications in flow chemistry research as well as educational requirements for universities. As a proof of concept, we conceptualized, developed, and tested a custom flow system that can be used to synthesize [18F]2-fluoro-2-desoxy-d-glucose ([18F]FDG), the most commonly used PET-tracer. This system was designed to perform the typical functions and operations required in radiotracer production i.e. radiofluorination, dilution, SPE-trapping, deprotection, and SPE-elution. With this proof-of-concept in hand, the system can be easily customized to produce other radiopharmaceuticals. Graphical Abstract
New thematic issue โ#Organofluorine chemistry VIโ edited by David O'Hagan, University of St Andrews, in the #DiamondOpenAccess ๐๐ #BJOC.
๐ https://www.beilstein-journals.org/bjoc/series/128/?M=y
Submission deadline ๐ July 31, 2024
Fluorinated Proteins Expressed in Human Cells for NMR Spectroscopy
A straightforward approach reaches fluorination efficiencies up to 60 %
#chemistry #chemistryviews #chemviews #chemiverse #nmr #fluorination
Beilstein-Institut
ChemistryViews
Bose-Einstein-Kondensat