Christos Argyropoulos, University of New Mexico Heavy user of both #flozins and #nsMRA >> your grandpa's #MRA (only in those who cannot get the former) #Nephjc
It seems the usual #EBM suspects are making snarky comments about #CONFIDENCE similar to their comments about #flozins #sglt2i in the years leading up to CREDENCE/DAPA-CKD/EMPA-KIDNEY.
It was obvious then (and it is now) that they don't understand how UACR works as a biomarker
It seems the usual #EBM suspects are making snarky comments about #CONFIDENCE similar to their comments about #flozins #sglt2i in the years leading up to CREDENCE/DAPA-CKD/EMPA-KIDNEY. It was obvious then (and it is now) that they don't understand how UACR works as a biomarker
If I were you I'd start praying that the #flozins and the #MRAs hold the fort. If not, not good things will happen by the mid 2030s
If I were you I'd start praying that the #flozins and the #MRAs hold the fort. If not, not good things will happen by the mid 2030s
Bluesky

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Nephrologist's take on the effect and impact of SGLT-2 inhibitors and GLP-1 RAs on Kidney Disease in people with diabetes

Nephrologist's take on the effect and impact of SGLT-2 inhibitors and GLP-1 RAs on Kidney Disease in people with diabetes - Download as a PDF or view online for free

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Nephrologist's take on the effect and impact of SGLT-2 inhibitors and GLP-1 RAs on Kidney Disease in people with diabetes

Nephrologist's take on the effect and impact of SGLT-2 inhibitors and GLP-1 RAs on Kidney Disease in people with diabetes - Download as a PDF or view online for free

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In case you are scratching your heads about the different cutoffs to use #flozins according to intended use:
Need total gfr to be high to remove sugar vs need to act on the hyperfiltering units (which could be few) to prevent bad kidney and heart clinical outcomes.