Inside the matrix: Nanoscale patterns revealed within model research organism.

#extracellular_matrix #Caenorhabditis

https://phys.org/news/2023-12-matrix-nanoscale-patterns-revealed.html

Inside the matrix: Nanoscale patterns revealed within model research organism

Species throughout the animal kingdom feature vital interfaces between the outermost layers of their bodies and the environment. Intricate microscopic structures—featured on the outer skin layers of humans, as one example—are known to assemble in matrix patterns.

Phys.org

Interesting perineuronal net (#PNNs) and #extracellular_matrix labelling strategy - knock in a fluorescent protein into the linker protein. Super promising for anyone looking into #parvalbumin #GABAergic neuronal anatomy.

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo
Lemieux et al., #preprint at biorxiv 2023
https://doi.org/10.1101/2023.11.29.569151

#neuroscience