PLOS BiologyApr 24, 2025
#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @PLOSBiology https://plos.io/42XBYfH
Werner syndrome exonuclease promotes gut regeneration and causes age-associated gut hyperplasia in Drosophila

Mutations in the Werner syndrome (WRN) gene cause premature aging during early adulthood, but the role of this exonuclease in natural aging remains unclear. This study shows that the Drosophila homolog WRNexo regulates the unfolded protein response of the endoplasmic reticulum in intestinal stem cells, promoting gut regeneration during injury, but also triggers gut hyperplasia during aging.

katch wreckNov 11, 2023

"In conclusion, the newly identified PARP1-CTF18-Polϵ #exonuclease axis and HDR act independently to prevent fork collapse at single-ended double-strand breaks. #Olaparib inhibits this axis, explaining the pronounced #cytotoxic effects of olaparib on HDR-deficient cells."

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad999/7369941

#polymerase #DNA #replication #mutations #cancer #oncology #cellBiology #genetics

The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands

Abstract. Leading-strand DNA replication by polymerase epsilon (Polϵ) across single-strand breaks (SSBs) causes single-ended double-strand breaks (seDSBs), whic

OUP Academic