katch wreck"Here we use a range of reporter proteins to demonstrate that their #chimeras with duplicated #receptor domains produce YES gate protein switches with large (up to 9,000-fold) dynamic ranges and fast (minutes) response rates. In such switches, the #epistatic interactions between largely independent synthetic #allosteric sites result in an OFF state with minimal background noise."
Development of epistatic YES and AND protein logic gates and their assembly into signalling cascades - Nature Nanotechnology
Protein-based nanobiosensors with two epistatically interacting synthetic allosteric regulatory systems result in YES gate protein switches with large dynamic ranges and fast response times. These biosensors enable construction of rapid diagnostic tests compatible with clinical chemistry analysers.