Cortisol treatment impairs path integration and alters grid-like representations in the male human entorhinal cortex

Stress impacts navigational performance and involves cortisol release, but how cortisol impacts brain functions supporting navigation remains unclear. This study in men shows that cortisol administration impairs path integration, a specific navigational process, and reduces grid-like brain activity patterns in the entorhinal cortex, offering new insights into the effects of stress on navigation.