Identification and characterization of a #SARS-CoV-2 #Mpro G23 deletion #ensitrelvir - #resistant mutant

· The #COVID19 antiviral #ensitrelvir (Xocova), was recently approved by the Food and Drug Administration
· New study in CELL reinforced that some people with #LongCOVID have autoantibodies that attack the body
[https://www.cell.com/cell/abstract/S0092-8674(26)00509-X]
· About one in six people with a documented COVID-19 case developed Long COVID, according to a new study published in JAMA Network Open
[https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2849452]

https://thesicktimes.org/2026/06/02/research-updates-june-2/

#ResearchUpdates #TheSickTimes #COVID

@feisty_lemming
Yes, the 9% stated by the article (from the international study) is very low. But that is good news, right? Even without any drug, the chance of catching an infection from another infected person in your same living space is very low.

From the study you shared, I see many of the vaccinated got sick from what they were supposedly vaccinated for!

@mikemccaffrey

#COVID #health #ensitrelvir #vaccine

@mikemccaffrey
According to their trial, without the drug, only 9% of people living in the same house with a symptomatic person also get sick. So your odds of getting sick are already very low. With the drug, 3% get sick, so your odds are not zero.

"9% of people who received a placebo within 72 hours of a housemate developing symptoms became symptomatic themselves, compared with only about 3% of those who got a five-day course of #ensitrelvir."

Is this drug worth the side effects?

#COVID

#Ensitrelvir for #Covid19 Postexposure #Prophylaxis in #Household Contacts

#Ensitrelvir for the #treatment of hospitalized adults with #COVID19: an international phase 3 randomized placebo-controlled trial, https://etidiohnew.blogspot.com/2026/04/ensitrelvir-for-treatment-of.html
#Ensitrelvir for the #treatment of hospitalized adults with #COVID19: an international phase 3 randomized placebo-controlled trial

#Antiviral efficacy of oral #ensitrelvir versus oral ritonavir-boosted #nirmatrelvir in #COVID19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial, https://etidiohnew.blogspot.com/2025/10/antiviral-efficacy-of-oral-ensitrelvir.html
#Antiviral efficacy of oral #ensitrelvir versus oral ritonavir-boosted #nirmatrelvir in #COVID19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial

Sporadic Occurrence of #Ensitrelvir #Resistant #SarsCoV2 #Japan, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/6/24-0023_article

Using the GISAID EpiCoV database, we identified 256 #COVID19 patients in Japan during March 31–December 31, 2023, who had mutations in the SARS-CoV-2 #NS5 conferring ensitrelvir resistance.

Sporadic Occurrence of Ensitrelvir-Resistant SARS-CoV-2, Japan

Sporadic Occurrence of Ensitrelvir-Resistant SARS-CoV-2, Japan

Emerging Infectious Diseases journal
''#Ensitrelvir #treatment of hamsters infected with the virus possessing Nsp5-M49L/E166A was ineffective; however, #nirmatrelvir or #molnupiravir treatment was effective. Therefore, it is important to closely monitor the emergence of ensitrelvir-resistant SARS-CoV-2 variants to guide antiviral treatment selection.''