New studies in mice and people find a mechanistic link between production of inflammatory forms of glycogen by a suite of gut bacteria and neuroinflammation characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

Summary: https://www.sciencealert.com/gut-bacteria-could-be-a-hidden-trigger-for-neurodegenerative-diseases

Original paper: https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01678-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS221112472501678X%3Fshowall%3Dtrue

#Science #Health #Dysbiosis #GutMicrobiome #ALS #Dementia

Gut Bacteria Could Be a Hidden Trigger For Neurodegenerative Diseases

Bacterial sugars in the gut could be a hidden contributor to two of the most serious neurodegenerative diseases that afflict the brain, new research suggests.

ScienceAlert
Gut #dysbiosis has been linked to #NeurologicalDisease, but what's the mechanism @DWeissLab &co show that a high-fat diet increases gut permeability, enabling bacterial translocation from gut to brain via the vagus nerve in mice @PLOSBiology https://plos.io/4ruE6EP
Translocation of bacteria from the gut to the brain in mice

Recent studies link gut dysbiosis to neurological disease, but the underlying mechanisms remain unclear. This study shows that a high-fat diet increases gut permeability and enables bacterial translocation from the gut to the brain via the vagus nerve in mice.

Microbial #dysbiosis alters chemical cues in the oral #microbiome, but how do commensals sense these? This study shows that #Streptococcus salivarius detects dysbiosis metabolites & repurposes a peptide #QuorumSensing receptor to drive antibacterial predation @PLOSBiology https://plos.io/4rtVSbf
Non-peptide dysbiosis metabolites reprogram a peptide quorum-sensing receptor to induce sustained predation in beneficial streptococci

Microbial dysbiosis alters chemical cues in the oral microbiome, but how commensals sense these changes is unclear. This study shows that Streptococcus salivarius detects dysbiosis metabolites and repurposes a peptide quorum-sensing receptor to drive sustained antibacterial predation, revealing a new form of interspecies chemical communication.

Here is your cue to take 2 full gentle breaths for 6 seconds in through the nose and 6 seconds out through the nose.

#stress #vagusnerve #dysbiosis #guthealth #health #breath

Vaginal condition treatment update: Men should get treated, too https://arstechni.ca/mqcx #bacterialvaginosis #microbiota #dysbiosis #partners #Health #ACOG
Vaginal condition treatment update: Men should get treated, too

For bacterial vaginosis, partners are part of the problem—and the solution.

Ars Technica

https://medicalxpress.com/news/2025-07-beneficial-bacteria-infant-guts-linked.html

Missing beneficial bacteria in infant guts linked to rising asthma and allergy cases

researchers highlight that while the term #dysbiosis or imbalance in the #microbiome is still up for debate, the strong correlation between microbiome composition and #infanthealth suggests that the absence of these key #Bifidobacterium strains represents a true dysbiosis in early life.

Missing beneficial bacteria in infant guts linked to rising asthma and allergy cases

Nearly one in four infants lacks enough healthy gut bacteria essential for training their immune systems, putting them at greater risk of developing non-communicable diseases (NCDs) such as allergies, asthma, and eczema by age 2.

Medical Xpress

I often have patients come in feeling... well, just not quite right. Maybe it's a grumbling tummy that won't settle, or a brain fog that just won't lift. #DigestiveHealth #dysbiosis #guthealth #GutMicrobiome #gutbrainaxis #probiotics

https://priya.health/gut-microbiome/

SciTech Chronicles. . . . . . . . .Feb 9th, 2025

  Invincibility is in oneself, vulnerability is in the opponent. Vol II No 35 165 links Curated Meet the Citizen Scientists Determining What...

La disfunción intestinal es un síntoma temprano y prevalente en pacientes con #enfermedadDeParkinson, y se asocia con progresión rápida de los síntomas.

Aunque en animales mostraron efectos promisorios de neuroprotección y disminución de síntomas, el #Transplante de #MicrobiotaFecal no ha demostrado aún su eficacia en humanos con #Parkinson

#TMF #FMT #Disbiosis #Dysbiosis #MicrobiotaIntestinal #FecalMicrobiotaTransplantation

https://jamanetwork.com/journals/jamaneurology/article-abstract/2821254

Fecal Microbiota Transplantation for Treatment of Parkinson Disease

This randomized clinical trial evaluates the safety and efficacy of fecal microbiota transplantation for the treatment of Parkson disease.