Researchers have identified the specific #neurogenic progenitor cells responsible for generating #dopaminergic neurons, alongside a distinct progenitor type that creates the necessary supportive environment for their survival.
#Neuroscience #DevelopmentalBiology #RegenerativeMedicine #Biology #sflorg
https://www.sflorg.com/2026/02/ns02162601.html
How dopamine producing neurons arise in the developing brain

The researchers also identified a second progenitor cell type that supports dopaminergic neuron development and survival

#DiscriminativeLearning enhances #sensory contrast for rapid, accurate decisions, but how? This study describes a sensory- #forebrain circuit centered on #dopaminergic short axon cells in the mouse #olfactory bulb, which refines sensory input during learning @PLOSBiology https://plos.io/4pvost3
Residential Proximity to Golf Courses Linked to Parkinson’s Disease

Living within a mile of a golf course is associated with a 126% increased risk for Parkinson’s disease (PD), possibly due to increased pesticide exposure, results of a population-based case-control study suggest.Results also showed drinking water from groundwater service areas with a golf course was associated with almost a twofold increased risk for the disease.Brittany Krzyzanowski, PhDThe study results imply that both vulnerable drinking water and airborne pollutant exposure may contribute to risk of developing PD near golf courses, study investigator Brittany Krzyzanowski, PhD, assistant professor, Barrow Neurological Institute, Phoenix, told Medscape Medical News.However, she cautioned that because the study

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#Dopamine signaling has been linked to #analgesia & #placebo effects, but is there a causal relationship? @bingellab &co show that enhancing #dopaminergic tone does not alter generation of positive treatment expectations or placebo analgesia #PLOSBiology https://plos.io/3ZC1Exf
Dopamine has no direct causal role in the formation of treatment expectations and placebo analgesia in humans

Dopamine signalling has been linked to pain analgesia and placebo effects but whether there is causal relationship remains unclear. This pre-registered study shows that enhancing dopaminergic tone does not alter the generation of positive treatment expectations or placebo analgesia.

Tradeoffs between rewards & costs involve the #dopaminergic system. @GJocham &co show that #dopamine & #acetylcholine have opposing effects on the modulation of specific components of #CostBenefit #DecisionMaking in humans #PLOSBiology https://plos.io/463uIik
Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans

Tradeoffs between potential rewards and associated costs involves the dopaminergic system, which antagonistically interacts with the cholinergic system. This study describes that dopamine and acetylcholine have opposing effects on the modulation of specific components of cost-benefit decision making in humans.