Cancer dormancy is a major hindrance to achieving complete clinical response in patients. This study uses a tumor stromal organoid and murine breast cancer model to reveal that chemotherapy injures stromal cells, but not dormant cancer cells directly; this stromal injury in turn invokes proinflammatory cytokine signaling and can awaken dormant cancer cells.
I'm now keeping an eye on: The SmPC for Docetaxel Hospira 10 mg/ml Concentrate for Solution for Infusion
πHospira UK Ltd
ππ #docetaxel.
I will let you know if it changes.
Our #STOPCAP #IPDMA of #docetaxel for advanced #prostateCancer #mHSPC came out this week in #LancetOncology!
Very excited about this: result of tremendous collaborative effort to obtain harmonized trial data, apply meticulous checking & processing, and carry out high-quality statistical analysis. Aim was to clarify patterns of survival within patient subgroups most & least likely to benefit.