Johannes W. DietrichJun 1, 2025

Relational stability is a major motif of the intertwined feedback loops of #thyroid #homeostasis. The integrated systemic roles and interdependent homeostatically regulated equilibrium of TSH, FT4 and #deiodinase​s maintains appropriate FT3 concentrations.

https://doi.org/10.1007/978-981-96-3682-2_2

Johannes W. DietrichApr 26, 2025

#Thyroid hormones play a pivotal role in #thermoregulation and the attunement to hot and cold #climate​s. Recent research found global patterns of variants in the UCP1 and UCP3 genes and #SPINA-GD (step-up #deiodinase activity), suggesting integrated adaptation.

https://doi.org/10.3390/biology14050454

SPINA TeamNov 11, 2023
Total step-up #deiodinase activity (#SPINA_GD) is upregulated in metabolic syndrome, as demonstrated by a strong correlation to the triglyceride-glucose index. https://pubmed.ncbi.nlm.nih.gov/37946276/ https://doi.org/10.1186/s40001-023-01501-z
Exploring the association between triglyceride-glucose index and thyroid function - PubMed

The present study established a noteworthy association between TyG and thyroid parameters, indicating a strong link between IR and thyroid dysfunction. Further investigations are warranted to validate these results.

PubMed
SPINA TeamFeb 17, 2023
Total #deiodinase activity (#SPINA_GD) correlates to bone mineral density and predicts the risk for #osteoporosis. https://pubmed.ncbi.nlm.nih.gov/36795243/ https://doi.org/10.1007/s40618-023-02035-1
Impaired sensitivity to thyroid hormone correlates to osteoporosis and fractures in euthyroid individuals - PubMed

In elderly euthyroid individuals, impaired sensitivity to thyroid hormones correlates to osteoporosis and fractures, independent of other conventional risk factors.

PubMed