Hội nhập transcriptome và connectome, SpaCon phát hiện mối liên hệ giữa biểu hiện gen và kết nối não. Mô hình này sử dụng thuật toán mã hóa đồ thị để dự đoán kết nối từ dữ liệu gen, phân loại chính xác các loại tế bào thần kinh. Độ chính xác cao, hiệu quả tính toán vượt trội, nghiên cứu trên nhiều loài. #KHCN #NgônNgữMôTếBào #Connectome #AI #BrainResearch #SpaCon #Genetics #Neuroscience #KHCNViệtNam

https://www.reddit.com/r/singularity/comments/1pncey4/integrative_analysis_of_spatial_transcript

🧠 New paper by Huang et al.: By using #pharmacological #fMRI and dynamic #connectome-based #PredictiveModeling, they show how #cortisol reshapes whole-brain #NetworkDynamics during emotional memory encoding. Trial-level analyses reveal distinct but increasingly integrated #arousal and #memory networks under #stress, supporting a hormonally driven "memory formation mode".

🌍 https://doi.org/10.1126/sciadv.adz4143

#Neuroscience #CognitiveNeuroscience #BrainNetworks #CogSci

🧠 New paper by Clark et al. (2025) shows that the #dimensionality of #PopulationActivity in #RNN can be explained by just two #connectivity parameters: effective #CouplingStrength and effective #rank. Uses networks with rapidly decaying singular value spectra and structured overlaps between left and right singular vectors. Could be useful for interpreting large scale population recordings and connectome data I guess:

🌍 https://doi.org/10.1103/2jt7-c8cq

#CompNeuro #NeuralDynamics #Connectome

Also, we do have a #PhD position open to continue this investigation with the aid of #connectome in collaboration with Nils Reinhard @nils-reinhard.bsky.social
See details at https://www.kofanchenlab.net/come-join-us
Come Join US

Fully funded PhD positions available Application deadline: 27 November 2025 for MIBTP / 11 December for CSC

Anne Churchland (CSHL) 2: Connecting movements & neural activity during decision-making

YouTube
Anne Churchland (CSHL) 1: How do brains decide?

YouTube

The #connectome may be important, but it does not seem to help understand neuronal activity patterns:

"Comprehensive neuronal identification enabled us to examine the relationship between whole-brain activity and the connectome but we found no strong correlations between them."

https://doi.org/10.1016/j.cell.2020.12.012

Replication: https://doi.org/10.1016/j.cub.2022.06.039

The structure of a nervous system is one thing, but its relation to NS function seems to be much more tenuous than we may have hoped for.

#neuroscience

How much can a #connectome tell us about the activity of neurons? It seems not all that much:

"neuronal perturbation often prompted responses from cells that had no anatomical connections to the target cell"

https://www.thetransmitter.org/connectome/worms-help-untangle-longstanding-brain-structure-function-mystery/

#neuroscience #biology

Worms help untangle brain structure/function mystery

The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in <em>C. elegans</em>. 

The Transmitter: Neuroscience News and Perspectives

We have received the reviews for our "Neural #Connectome of the Ctenophore Statocyst" paper from @eLife

"This fundamental work significantly advances our understanding of gravity sensing and orientation behavior in the ctenophore, an animal of major importance in understanding the evolution of nervous systems. Through comprehensive reconstruction with volumetric electron microscopy, and time-lapse imaging of cilia motion ... []"

https://www.biorxiv.org/content/10.1101/2025.06.26.661250v2
#ctenophore #neuroscience