Parasite Power Plays: How Do Coinfections Shape Host Genetics and Traits?
Bolnick et al. find that coinfections reveal a complex battle of genetics.
Summary & Analysis by Elvira D’Bastiani
https://www.amnat.org/an/newpapers/Nov-2024-Bolnick.html
<p>Read about “The Dominance of Coinfecting Parasites’ Indirect Genetic Effects on Host Traits” by Daniel I. Bolnick, Sophia Arruda, Christian Polania, Lauren Simonse, Arshad Padhiar, Maria L. Rodgers, and Andrea J. Roth-Monzón (Nov 2024)</p><br/>
#HK, Severe case of #influenza A #H1N1 and invasive #pneumococcal #coinfection in unvaccinated #child https://www.info.gov.hk/gia/general/202501/11/P2025011100225.htm
The clinical diagnosis was co-infection with influenza A and severe invasive pneumoccocal disease complicated by pneumonia. He remains hospitalised in a serious condition," a spokesman for the CHP said.
#HK CHP investigates one imported #coinfection case of #Zika virus and #dengue fever https://www.info.gov.hk/gia/general/202404/12/P2024041200729.htm
The case involves a 16-year-old male patient with good past health, who had developed a #fever, #headache and #pain behind the #eyes since April 7... the patient had stayed in Ko Lanta Island, #Thailand from March 28 to April 3, and returned to Hong Kong on April 6.
#WHO (13 February 2024). Disease #Outbreak #News; Avian #Influenza A(#H10N5) and Influenza A(#H3N2) #coinfection - #China. Available at https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON504
-- 1 confirmed case of #human #coinfection with #H10N5 virus & seasonal influenza A(#H3N2). This is 1rst case of #human infection with avian influenza H10N5 reported globally. Case occurred in a female farmer over 60 yrs, with chronic comorbidities, from Anhui Province. Onset on 30 Nov 23 & passed away on 16 Dec 2023.
SARS-CoV-2 coinfections may lead to recombination events which could be important in the emergence of new variants. Here, the authors develop an automated bioinformatics pipeline to identify coinfections in genomic data and test it on >2 million publicly available raw read data sets collected globally.
#Coinfection of #dengue and #Zika viruses mutually enhances viral replication in the #mosquito #AedesAegypti
Daniel Chieh-Ding Lin, Shih-Che Weng , Po-Nien Tsao, Justin Jang Hann Chu, Shin-Hong Shiao
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Parasit Vectors, 2023 May 11
"Abstract
Background: The mosquito Aedes aegypti transmits two of the most serious mosquito-borne viruses, dengue virus (DENV) and Zika virus (ZIKV), which results in significant human morbidity and mortality worldwide. The quickly shifting landscapes of DENV and ZIKV endemicity worldwide raise concerns that their co-circulation through the Ae. aegypti mosquito vector could greatly exacerbate the disease burden in humans. Recent reports have indicated an increase in the number of co-infection cases in expanding co-endemic regions; however, the impact of co-infection on viral infection and the detailed molecular mechanisms remain to be defined.
Conclusions: Our results suggest that DENV2 and ZIKV simultaneously establishing infection in the Ae. aegypti mosquito vector may augment one another during replication. The data also implicate the homologous NS5 protein as a key intersection between the flaviviruses in co-infection, highlighting it as a potential target for vector control."
Our results suggest that DENV2 and ZIKV simultaneously establishing infection in the Ae. aegypti mosquito vector may augment one another during replication. The data also implicate the homologous NS5 protein as a key intersection between the flaviviruses in co-infection, highlighting it as a potenti …
Read now ahead of print: "Age Structure Eliminates the Impact of Coinfection on Epidemic Dynamics in a Freshwater Zooplankton System" by Clay et al. https://www.journals.uchicago.edu/doi/10.1086/726897
#zooplankton #freshwater #epidemic #dynamics #coinfection #ageDynamics