https://www.esquerda.net/artigo/vereadora-do-bloco-questiona-moedas-sobre-tacho-do-chega-nos-servicos-sociais-da-cml/97239
A evidência de que o chega não quer acabar com a corrupção, quer o monopólio!!! Moedas é um corrupto troca tintas, fica tudo no mesmo saco...mafia de direita sem escrúpulos.
#CML #CORRUPÇÃO #Moedas
Vereadora do Bloco questiona Moedas sobre “tacho” do Chega nos Serviços Sociais da CML

Carolina Serrão quer saber se o Departamento de Transparência da autarquia emitiu parecer sobre a nomeação da namorada do vereador do Chega para vogal da administração dos Serviços Sociais da CML.

Handboek voor stedelijke vergroening

Hoe wetenschap beleid vormgeeft: ‘Als onderzoeker wordt mijn werk pas echt relevant als het in de samenleving wordt toegepast’

https://www.universiteitleiden.nl/nieuws/2025/12/hoe-wetenschap-beleid-vormgeeft-als-onderzoeker-wordt-mijn-werk-pas-echt-relevant-als-het-in-de-samenleving-wordt-toegepast

@RoyRemme @OliverTaherzadeh @JoeriMorpurgo @universiteitleiden #publicatie #VN #EU #milieu #rapport #klimaat #beleidsmakers #biodiversiteit #CML @HongyiCai @AysegülÇelik #GreenGrocer #BioAgora @mijnAmstelveennieuws #MorpurgoMedia

Hoe wetenschap beleid vormgeeft: ‘Als onderzoeker wordt mijn werk pas echt relevant als het in de samenleving wordt toegepast’

Groene steden en een goed beschermd voedselsysteem: Roy Remme en Oliver Taherzadeh onderzoeken manieren om dit te bereiken. Maar hoe kunnen hun wetenschappelijke bevindingen leiden tot maatschappelijke verandering? Ze delen hun ervaringen met beleidsinitiatieven.

Universiteit Leiden
To anyone living in #Columbus or even just #Ohio in general, the Columbus metropolitan #library now offers subscriptions to the #newyorktimes! This includes the daily #crossword, both the usual one and the #mini, any of the other #games, and, of course, all of their #news articles. I only heard about it from a friend and the only “announcement” I could find was on Facebook, whose video I’ve attached here (maybe #CML will get on Fedi someday? 🤔), so I thought I’d share!

on the verge of getting a Telegraf docker container working in Cisco Modeling Labs

oddly satisfied

#cisco #cml #homelab

I’ve written a step-by-step guide to deploying Cisco Modeling Labs (CML) 2.9 to Azure using Terraform. It is meant for people new to cloud or Terraform deployment. It’s a bit of a complicated process so I hope my guide is helpful!

See my blog post for more details: https://gryba.ca/posts/How-to-deploy-CML-2.9-to-Azure-using-Terraform/

#Cisco #CML #Azure #Terraform

How to deploy CML 2.9 to Azure using Terraform

This guide provides step-by-step instructions for deploying CML 2.9 to Azure using Terraform. It is meant for people new to IaaS or Terraform deployment.

Distinct Functions of the PH Domain in BCR/ABL p210 Isoform: Interaction with Cytoskeletal and Membrane Remodeling Proteins - #BCRABL #cortactin #FBP17 #PHdomain #CML #GSTpulldown #proteinproteininteractions - https://link.springer.com/article/10.3103/S0095452725020045
Distinct Functions of the PH Domain in BCR/ABL p210 Isoform: Interaction with Cytoskeletal and Membrane Remodeling Proteins - Cytology and Genetics

Abstract The BCR/ABL fusion protein, generated by the Philadelphia chromosome translocation, drives chronic myelogenous leukemia (CML) and other myeloproliferative disorders. The p210 isoform includes a pleckstrin homology (PH) domain absent in the p190 isoform, which is linked to acute lymphoblastic leukemia (ALL). This structural difference may underlie the distinct subcellular localization and signaling profiles of the two isoforms. Here, we investigate the role of the PH domain of BCR in interactions with cortactin and FBP17, proteins involved in cytoskeletal remodeling and membrane dynamics. Using GST-pulldown assays and western blotting, we demonstrated direct interactions between the PH domain of BCR and both cortactin and FBP17. Colocalization studies, supported by confocal and STED microscopy, revealed that cortactin colocalizes with the PH domain of BCR in the centrosomal and perimembrane regions of cells. Notably, the SH3 domain of cortactin was not required for this interaction, but full-length cortactin was essential, suggesting that other domains mediate binding. These findings highlight the role of the PH domain in directing BCR/ABL to the centrosome, where it interacts with cortactin to potentially influence actin dynamics and vesicular trafficking. This centrosomal localization may spatially restrict the constitutive tyrosine kinase activity of ABL, contributing to the less aggressive phenotype of p210-associated CML compared to p190-driven ALL. Understanding the role of the PH domain as a key structural difference between p210 and p190 is critical for elucidating the molecular basis of BCR/ABL-mediated leukemogenesis. Future studies will explore the phosphorylation of cortactin and FBP17 by ABL kinase and the domains responsible for these interactions.

SpringerLink
CONNECTED MINERALS LIMITED ( #CML ) has released " Pallingup Project in Western Australia Expanded " on Fri 30 May at 16:08 AEST #Pilbara #Mining #Gold #Australia #Metals
https://grafa.com/asset/connected-minerals-limited-30719-cml.asx?utm_source=asxmktsensitive&utm_medium=mastodon&utm_campaign=cml.asx