Amelia Cervera 🧬Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators.
#circRNA #RNA #AgingResearch #Drosophila
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00256-6
Circular RNAs derived from MIR156D promote rice heading by repressing transcription elongation of pri-miR156d through R-loop formation.
Circular RNAs derived from MIR156D promote rice heading by repressing transcription elongation of pri-miR156d through R-loop formation - Nature Plants
This study uncovers a mechanism of rice heading regulation mediated by circular RNAs (ciMIR156Ds) derived from pri-miR156d that refine the aging-dependent expression of miR156 through R-loop formation.
The therapeutic potential of circular RNAs.
#CircularRNA #circRNA #RNAbasedTherapy #Review
https://www.nature.com/articles/s41576-024-00806-x
#CircularRNA #circRNA #RNAbasedTherapy #Review
https://www.nature.com/articles/s41576-024-00806-x
The therapeutic potential of circular RNAs - Nature Reviews Genetics
Circular RNAs have gained attention for their stability, immunological advantages and regulatory functions, making them a promising modality in multiple therapies. This Review discusses the therapeutic prospects of circular RNA-based approaches and the emerging role of circular RNAs as biomarkers in disease.
Spektrum (inoffiziell)Mit RNA-Impfstoffen haben Pharmafirmen riesige Gewinne erzielt. Entsprechend groß ist das Interesse an der nächsten Generation der RNA-Arzneimittel, die auf Ringmolekülen basieren.#RNA #CircularRNA #CircRNA #RingförmigeRNA #RNA-Therapeutika #RNA-Impfstoffe #Nukleinsäuren #Medizin
Heilende Ringe aus RNA
Heilende Ringe aus RNA
katch wreck"Analysis of nuclear circRNA-binding proteins reveals that interaction between IGF2BP1 & circRNA is enhanced by Ran-GTP. The formation of circRNA export complexes in the #nucleus is promoted by Ran-GTP through its interactions with exportin-2, #circRNA & IGF2BP1. Our findings demonstrate that adaptors such as IGF2BP1 that bind directly to circular RNAs recruit Ran-GTP & exportin-2 to export circRNAs in a mechanism..analogous to #protein export, rather than #mRNA export"
The EMBO Journal#CircRNA CircPVT1 promotes ER-positive #breastcancer tumorigenesis and drug resistance by targeting #ESR1 and #MAVS
How is #selfrenewal of #intestinal #stemcells at the crypt base regulated?
Zusen Fan and coworkers identify #circBtnl1 circular RNA #circRNA that inhibits ISC self-renewal via #mRNA decay of #Sox9 #transcription activator #Atf4