Very proud of our latest #paper out today in @sciencemagazine where we show that platelets capture cell-free DNA from their surrounding!

This was a project initiated and driven by Bethan Psaila here in Oxford. My team performed #genomics analyses to show that platelet-derived #cfDNA resembles plasma cfDNA in terms of #fragmentomics, #epigenetics and mutation patterns.

Read the paper here: https://www.science.org/doi/10.1126/science.adp3971

Or check out the summary by no other than Dennis Lo 😱:
https://www.science.org/doi/10.1126/science.aea0555

Seattle obstetric researchers at the University of Washington have developed a test that can predict devastating preeclampsia with 80% accuracy months before its actual occurrence. #preeclampsia #cfDNA #pregnancy #women
https://www.instagram.com/drhowardsmithreports/reel/DGV5FSROObD/
Howard G. Smith MD, AM on Instagram: "Blood Test Predicts Preeclampsia This condition of late pregnancy, heralded by dangerously high blood pressures and organ failure, kills 70,000 women worldwide each year. Seattle obstetricians and precision medicine researchers at the University of Washington now announce in the journal Nature a test that can predict this devastating complication with 80% accuracy months before its actual occurrence. Using a machine learning analysis of cell-free DNA from the placenta shed into 1,854 blood samples from pregnant women, the researchers pinpointed signs of early tissue dysfunction associated with preeclampsia. With further test refinement and inclusion with standard pregnancy test batteries, this cell-free DNA assessment could save many lives. https://medicalxpress.com/news/2025-02-blood-cell-free-dna-placenta.html https://www.nature.com/articles/s41591-025-03509-w #preeclampsia #cfDNA #pregnancy #women"

0 likes, 0 comments - drhowardsmithreports on February 21, 2025: "Blood Test Predicts Preeclampsia This condition of late pregnancy, heralded by dangerously high blood pressures and organ failure, kills 70,000 women worldwide each year. Seattle obstetricians and precision medicine researchers at the University of Washington now announce in the journal Nature a test that can predict this devastating complication with 80% accuracy months before its actual occurrence. Using a machine learning analysis of cell-free DNA from the placenta shed into 1,854 blood samples from pregnant women, the researchers pinpointed signs of early tissue dysfunction associated with preeclampsia. With further test refinement and inclusion with standard pregnancy test batteries, this cell-free DNA assessment could save many lives. https://medicalxpress.com/news/2025-02-blood-cell-free-dna-placenta.html https://www.nature.com/articles/s41591-025-03509-w #preeclampsia #cfDNA #pregnancy #women".

Instagram
First talk of the conference: Yuval Dor presenting applications of #epigenetic methylation maps of immune cells for detecting immune response and cancer initiation from #cfDNA
Breast Milk Helps Early Cancer Detection:
Analysis of breast milk and detection of cell-free tumor DNA, a liquid tumor biopsy, is nearly 11 times more effective than using blood. #breastmilk #breastcancer #liquidbiopsy #earlydetection #cfDNA
https://www.instagram.com/p/C0pH9cArYEY/
Promising Liquid Biopsy Assay For Ovarian Cancer: A liquid biopsy system called OvaPrint is capable of pinpointing high-grade serous ovarian cancer with an overall accuracy of 91%. #ovariancancer #liquidbiopsy #ovaprint #usc #cfDNA https://www.instagram.com/p/Cy_dyL1RlWX/

Epigenetic liquid biopsies reveal elevated vascular endothelial cell turnover and erythropoiesis in asymptomatic COVID-19 patients.

There is tissue damage even among those who had COVID but no symptoms.

Patients showed elevated levels of vascular endothelial cell and erythroblast cfDNA, suggesting that sub-clinical vascular and erythrocyte turnover are universal features of COVID-19, independent of disease severity.

https://www.biorxiv.org/content/10.1101/2023.07.28.550957v1

#Asymtomatic #Damage #cfDNA

https://icemsg.org/2023/08/03/an-important-preprint/

A DNA urine test for brain tumors

Innovation Toronto
Excited to present our new preprint on nucleosome reorganisation in breast cancer! https://www.biorxiv.org/content/10.1101/2023.04.17.537031v1 It's a large project, mapping nucleosome repositioning in paired normal and tumour tissues and cell-free DNA from the same patients #TFbinding #cfDNA #H1X #5mC #LiquidBiopsy

#GQ2023 β€” 10th Gene Quantification Event in #Freising is great because you can learn for example about #NGS, #qPCR, #dPCR, #biomarkers, Spatial-#Transcriptomics, #LiquidBiopsy & Circulating Nucleic Acids by great scientists like Jim #Huggett (#dMIQE), Stephen #Bustin (https://en.wikipedia.org/wiki/Stephen_Bustin), Michael W. #Pfaffl (https://scholar.google.de/citations?user=mYAWj3gAAAAJ&hl=de) or Jo #Vandesompele (famous for #qBase, #geNorm, ...) https://gene-quantification-2023.events/

#cfdna #LiquidBiopsy #spatialtranscriptomics #cancer

Stephen Bustin - Wikipedia

Graduate MSc/PhD applications due March 1st for most McMaster Health Sciences programs - please contact me if you are interested in #genomics #epigenomics #obgyn #pregnancy #cfDNA #bioinformatics #computationalbio

Please RT and or share with people you think may be interested!