Giuseppe MichieliAug 7, 2024

#Structural #basis of #mpro of #MERS-CoV bound to antineoplastic #drug #carmofur, Biochem Biophys Res Commun.: https://www.sciencedirect.com/science/article/abs/pii/S0006291X24010052?via%3Dihub

Highlights:
* The crystal structure of MERS-CoV Mpro in complex with carmofur.
* The structural basis of MERS-CoV Mpro binding to the inhibitor carmofur.
* Structural comparison of carmofur with SARS-CoV-2 Mpro and MERS-CoV Mpro.

Structural basis of main proteases of MERS-CoV bound to antineoplastic drug carmofur

Recurrent epidemics of coronaviruses have posed significant threats to human life and health. The mortality rate of patients infected with the Middle …