#HLPs are dead
#HIV particles hosting a comprehensive set of HIV proteins that increase immune responses without infecting a person. When compared with other potential cure approaches, HLP is an affordable
#biotherapeutic and can be administered by
#intramuscular #injection – similar to the seasonal flu vaccine.
#Virology #Medical #Microbiology #Pharmaceutical #sflorghttps://www.sflorg.com/2024/03/vi03262401.html 
Researchers a step closer to a cure for HIV
HIV is a retrovirus that attacks the body’s immune system and if left untreated, can lead to acquired immunodeficiency syndrome (AIDS).
Microbiome engineering: engineered live biotherapeutic products for treating human disease
The human microbiota is implicated in many disease states, including neurological disorders, cancer, and inflammatory diseases. This potentially huge impact on human health has prompted the development of microbiome engineering methods, which attempt to adapt the composition and function of the human host-microbiota system for a therapeutic purpose. One promising method is the use of engineered microorganisms that have been modified to perform a therapeutic function. The majority of these products have only been demonstrated in laboratory models; however, in recent years more concepts have reached the translational stage. This has led to an increase in the number of clinical trials, which are designed to assess the safety and efficacy of these treatments in humans. Within this review, we highlight the progress of some of these microbiome engineering clinical studies, with a focus on engineered live biotherapeutic products.
Development of a live #biotherapeutic throat spray with lactobacilli targeting respiratory viral infections -
https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.14189
Scientific Frontline
Vivek Mutalik