🧠 New paper by Deistler et al: #JAXLEY: differentiable #simulation for large-scale training of detailed #biophysical #models of #NeuralDynamics.

They present a #differentiable #GPU accelerated #simulator that trains #morphologically detailed biophysical #neuron models with #GradientDescent. JAXLEY fits intracellular #voltage and #calcium data, scales to 1000s of compartments, trains biophys. #RNNs on #WorkingMemory tasks & even solves #MNIST.

🌍 https://doi.org/10.1038/s41592-025-02895-w

#Neuroscience #CompNeuro

🧠 New preprint by Chintaluri et al. (2025): An ion channel #omnimodel for standardized #biophysical #neuron #modelling. A unified #HodgkinHuxley formalism applied to >3,500 ion channel models from #ModelDB. Enables cross-model comparison, #clustering, and reproducible simulation through a shared parametrization:

🌍 https://doi.org/10.1101/2025.10.03.680368

#CompNeuro #Neuroscience #Reproducibility

Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Here’s a summary from our JC:

🌍 https://www.fabriziomusacchio.com/blog/2025-06-29-astrocyte_enhance_plasticity/
📝 https://doi.org/10.1038/s42003-024-06540-8

#CompNeuro #Neuroscience

#Biophysical #principles predict #fitness of #SARS-CoV-2 #variants, Proc Natl Acad Sci USA: https://www.pnas.org/doi/abs/10.1073/pnas.2314518121?af=R

Our #study sheds light on the impact of specific #mutations on viral fitness and delivers a #tool for predicting the future epidemiological #trajectory of previously unseen or emerging low-frequency variants.

#Road building almost always precedes #forest loss, and road density is by far the strongest correlate of #deforestation out of 38 #biophysical and #socioeconomic factors.
Findings of the study imply that the most vital #conservation function of protected areas is limiting roads and road-related environmental disruption. They suggest that burgeoning, poorly studied ghost roads are among the gravest of all direct #threats to #tropical forests.

https://www.nature.com/articles/s41586-024-07303-5

#asia #nature #environment