Genetic changes sustaining the development of #CancerOfUnknownPrimary (CUP) remain elusive. New study reports a novel activating mutation of the #AxonGuidance gene #PLXNB2 that sustains proliferative autonomy and confers invasive properties to CUP stem cells, in EGFR-dependent manner.

By E. Giraudo, L. Tamagnone & colleagues

šŸ‘‰ https://doi.org/10.15252/emmm.202216104

The #Cerebellin family of proteins is known to influence #Synapse formation & function. @le_mccorm & @stephgupton1 explore a #PLOSBiology study that identifies a new role for Cerebellin-1 in #AxonGuidance. Primer: https://plos.io/3VdLdBF Paper: https://plos.io/3ghYJ8M
Cerebellin-1 leads the way

The cerebellin family of proteins influences synapse formation and function. In this issue of PLOS Biology, Han and colleagues identify a new role for Cerebellin-1 in axon growth and guidance.

The #Cerebellin family of proteins is known to influence #Synapse formation & function. @le_mccorm & @stephgupton1 explore a #PLOSBiology study that identifies a new role for Cerebellin-1 in #AxonGuidance. Primer: https://plos.io/3VdLdBF Paper: https://plos.io/3ghYJ8M
Cerebellin-1 leads the way

The cerebellin family of proteins influences synapse formation and function. In this issue of PLOS Biology, Han and colleagues identify a new role for Cerebellin-1 in axon growth and guidance.

The #Cerebellin family of proteins is known to influence #Synapse formation & function. @le_mccorm & @stephgupton1 explore a #PLOSBiology study that identifies a new role for Cerebellin-1 in #AxonGuidance. Primer: https://plos.io/3VdLdBF Paper: https://plos.io/3ghYJ8M
Cerebellin-1 leads the way

The cerebellin family of proteins influences synapse formation and function. In this issue of PLOS Biology, Han and colleagues identify a new role for Cerebellin-1 in axon growth and guidance.

Because the search function here doesn't work so well, as I've seen others do, here is a list of hashtags # I'm following (some of which I'm also adding to my profile):

#DevBio
#DevBiol
#Development
#Myoverse (as a possible equivalent of #Myotwitter )
#Morphogenesis
#Regeneration #MuscularDystrophy
#FSHD
#Mechanobiology
#CellBiology
#Neurobiology
#NeuroDev
#Imaging
#biorxiv
#preLights
#Microscopy
#axonguidance

#introduction I’m Anne, Professor in #neuroscience at Fribourg University. In our #Drosophila lab, we work on neuronal circuits for reproductive behavior and acoustic communication, sex differences of the nervous system and the signaling function of seminal fluid. I like #arthopods #sexualselection #matechoice #spermcompetition #microscopy and #connectomics
Used to work with #zebrafish #development #axonguidance
Also teaching and keen on #embryology and #histology for medical students...