PLOS BiologyChronic #trypanosome brain infection induces meningeal responses resulting in ectopic lymphoid aggregates containing #autoreactiveBcells; #autoantigens include MBP, consistent with experimentally observed #demyelination @Jquintanalcala &co #PLOSBiology https://plos.io/3R8xgpH
The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection
This study shows that chronic brain infection with African trypanosomes induces broad meningeal responses resulting in the development of ectopic lymphoid aggregates containing autoreactive B cells; myelin basic protein is one of the autoantigens detected by autoreactive B cells, consistent with the cortical demyelination observed in experimental infections.