Pipeline release! nf-core/funcscan v3.0.0 - v3.0.0 - French Chocolatine - 2025-10-04!
Please see the changelog: https://github.com/nf-core/funcscan/releases/tag/3.0.0
#amp #amr #antibioticresistance #antimicrobialpeptides #antimicrobialresistancegenes #arg #assembly #bgc #biosyntheticgeneclusters #contigs #function #metagenomics #naturalproducts #screening #secondarymetabolites #nfcore #openscience #nextflow #bioinformatics
đŚ What makes antimicrobial peptides so selective against bacteria and cancer cells, while leaving healthy cells intact?
đ Unlocking the specificity of antimicrobial peptide interactions for membrane-targeted therapies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.04.022
đ CSBJ Nanoscience & Advanced Materials: https://csbj.org/nano
#AntimicrobialPeptides #DrugDiscovery #MolecularDynamics #Biophysics #MembraneBiology #Bioinformatics #PeptideTherapeutics
Some extraordinary news for the lab just dropped, we need sometime for full disclosure
...err, we also got two papers published:
#CheesyFungi new shades of blue produced by crossing domesticated chees-making fungi @PLOS
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011669
#CoEvoSymb a kingdom wide search for #AntimicrobialPeptides transporters
https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.001380
Understanding the genetic determinants underlying quantitative traits is crucial for our understanding of adaptation and for improving varieties in domesticated organisms. Penicillium roqueforti is the mold used worldwide for blue cheese making. The two domesticated cheese populations in P. roqueforti each display very little genetic diversity, but are highly differentiated. We therefore generated progenies between these populations despite reduced fertility. As expected, offspring displayed high variation in multiple traits important for cheese making, involved in aspect, flavor or food security, such as color, lipolysis, proteolysis and extrolite production. We detected genetic determinants for most of these traits, paving the way for generating new varieties. Several genomic regions impacted multiple traits, as often found in domesticated organisms. These findings further contribute to our understanding of the genetic mechanisms underlying rapid adaptation to new environments, likely involving master gene regulation impacting multiple genes.
Pipeline release! nf-core/funcscan v2.1.0 - v2.1.0 - Egyptian Koshari - 2025-03-05!
Please see the changelog: https://github.com/nf-core/funcscan/releases/tag/2.1.0
#amp #amr #antibioticresistance #antimicrobialpeptides #antimicrobialresistancegenes #arg #assembly #bgc #biosyntheticgeneclusters #contigs #function #metagenomics #naturalproducts #screening #secondarymetabolites #nfcore #openscience #nextflow #bioinformatics
Antimicrobial peptides have been suggested as a solution to combat the escalating public health threat of antibiotic resistance. This study demonstrates that random peptide mixtures are significantly better than traditional single-sequence antimicrobial peptides at preventing the development of resistance in Pseudomonas aeruginosa.
New on my "to-read" list: #AntimicrobialPeptides (AMPs or HDPs) are key to fight infections. But there's a building literature on their knock-on effects. This study proposes the AMP "Attacin D" is actually autotoxic, damaging #Drosophila kidneys (MTs) when induced.
Referenced link: https://phys.org/news/2023-05-biopharming-technique-yields-cost-effective-environmentally.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-05-biopharming-technique-yields-cost-effective-environmentally.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1656311395841966083#m
Biopharming technique yields cost-effective and environmentally friendly #antimicrobialpeptides @kaust_news @NatureComms https://www.nature.com/articles/s41467-023-37003-z https://phys.org/news/2023-05-biopharming-technique-yields-cost-effective-environmentally.html
Another hot-off-the-press preprint on #Drosophila host - #microbiome interactions:
Lactobacillus plantarum is resistant to host #antimicrobialpeptides (AMPs) thanks to characteristics of its peptidoglycan that make its cell wall less sensitive to AMPs than other #bacteria. đŚ
Definitely adding to my reading list! Congrats to Aranzazu et al. and Igor Iatsenko, whose new lab has been knocking it out of the park! âž
Referenced link: https://phys.org/news/2023-02-ai-based-finder-antimicrobial-peptides.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-02-ai-based-finder-antimicrobial-peptides.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1628776964214472710#m
Researchers develop a new AI-based 'finder' of #antimicrobialpeptides https://onlinelibrary.wiley.com/doi/10.1002/pro.4529 https://phys.org/news/2023-02-ai-based-finder-antimicrobial-peptides.html
nf-core
CSBJ
Jan Taubenheim
Genetics Ecology and Evolution
PLOS Biology
MAHanson
Phys.org
MAHanson