Bart De Strooper presented at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathophysiological evolution of Alzheimer's disease, https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade

My own transition from amyloid plagues to p-tau and tangles was retarded by a four years' anti-amyloid therapy in a clinical reaearch project during 2017-22 (aducanumab). Sadly, the most probable explanation for my rapidly worsening cognitive problems may indeed be the tau-tangles, which I somehow avoided earlier. I know there are experimental therapies around somewhere for those gremlins too, but sadly not within my own reach. With respect to my AD, I'm afraid, it's "too late, my friend".

I encourage anybody with a slowly lethal disease to keep mentally in touch with it as long as you can. That's what we human beings were made for. 🤗

#alzheimer #ad #at #disease #medical #amyloid #tau #lethal #sairaus #alzForum #realism #humanity #reflection #thinking #dying #terminallyill #metacognition #tietoisuus #consciousness

HAI2026 konferenssin uutisia kootusti, https://www.alzforum.org/news/conference-coverage/human-amyloid-imaging-conference-hai2026

Vastaavasti 2025 lopun CTAD:ista https://www.alzforum.org/news/conference-coverage/clinical-trials-alzheimers-disease-ctad-2025, ja kesän AAIC:ista https://www.alzforum.org/news/conference-coverage/alzheimers-association-international-conference-aaic-2025

#alzheimer #dementia #memory #muisti #tutkimus #research #clinical_trials #news #alzForum #amyloid #sairaus #imaging #tau #medical

An interesting open expert question regarding the approval of Alzheimer immuno-therapies on the basis of amyloid-removal alone, https://www.alzforum.org/news/research-news/it-time-approve-drugs-based-amyloid-removal

The question is framed with Aisen et.al's open-access article in A & D Perspectives, https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14342

The answers may turn out to be the most interesting part, at least with respect to staunch "trenchlines", though both articles contain lots of concise up-to-date information.

My own interest stems in part from first-hand experience as a guinea-pig in one of those therapies during 2017-22.

#ad #alzheimers #amyloid #immunothreapy #drugs #dementia #query #alzForum #clinical #neurology #geriatrics #medicine

CTAD 2024 news about clinical trials for AD: https://www.alzforum.org/news/conference-coverage/clinical-trials-alzheimers-disease-ctad-2024-17th

#ad #alzheimer #dementia #clinicalTrials #news #AlzForum #muisti #tutkimus #research

A long-awaited AlzForum's take on the news that ApoE4 homozygotism means in fact an AD pathology (though not necessarily dementia before death), https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers

The comments-section gives a glimpse of some of the trenchlines regarding the treatment of dementia, but I guess the prevention-camp has only just been strirred up from their Sleeping Beauty's slumber.

I, as an example, still have only a 1 % measured risk of acquiring AD, according to some widely used screens, and no "preventable risk factors" except maybe age. Too bad, my genetic inheritance seems to have been enough to skew the Amyloid-Beta balance early on. Luckily, I was recruited to the aducanumab-study for four years (a precursor of lecanemab with more severe side-effects), and probably got some more years to be able to think things like these.

#alzheimer #research #medical #APOE4 #alzForum #dementia #ad #alzheimers #amyloid #lecanemab #aducanumab #prevention #cure

"Kuopiossa leikellään elävien ihmisten aivoja", voisi kai joku lehti otsikoida.

Kyse on kuitenkin biopsioista hydrokefaliaa sairastavilla, ja näytteet olennainen osa mittavaa neurodegeneraatio-tutkimusten organisaatiota, https://www.alzforum.org/news/research-news/fresh-brain-every-friday-biopsies-transform-alzheimers-science.

Loput 5-osaisesta AlzForum-artikkelista löytää tuota kautta, osa 2 selostaa yhden operaation kulkua realistisesti, osa 4 tapailee kytkentää AT-tutkimukseen ja 5 biopankkailee.

#brain #biopsy #research #medical #kuopio #finland #alzforum

Kiintoisaa pohdintaa siitä, millainen olisi "kliinisesti merkittävä" hyöty uusimmista Alzheimerin taudin etenemisen jarruista, https://www.alzforum.org/news/research-news/no-easy-answers-clinical-meaningfulness-alzheimers-treatments. Etenkin kommenteissa pilkahtaa epäilys "maalitolppien siirrosta" (Schneider). Artikkeli toimii samalla realistisena tilannetietona siitä, missä sairauden lääkehoidon eturintama sijaitsee nykyään. Näkymä on koko lailla toinen kuin populaarissa "tiedeuutisoinnissa".

#alzheimers #clinical #treatment #AlzForum #aivoterveys