Mastodawn

Amyotrophic lateral sclerosis (ALS) progresses through a sequential, domino-like cascade that begins with early cellular breakdown inside motor neurons and is subsequently amplified by a damaging inflammatory immune response in the bloodstream and spinal cord.
Neurology #Neuroscience #Neurogenomics #Immunology #ALS #sflorg
https://www.sflorg.com/2026/05/ns05182604.html

ALS Chain Reaction: How Inflammation Drives Progression

Discover how ALS progresses via a domino-like cascade, where early nerve cell breakdown triggers a damaging immune response that worsens the disease.

Dagger ☀️3d ago

Jetzt: Gehirn-Computer-Schnittstelle auf Stage 3 der #rp26. #als

Das Versprechen: Allein durch Denken etwas steuern können.

NewsletterTF 4d ago

Leigh Recounts Dane's Passing, Emphasizes His Fierce Fatherhood and ALS Advocacy

Chyler Leigh shares memories of Eric Dane, focusing on his fatherhood and ALS advocacy after his recent passing.

#EricDane, #ChylerLeigh, #ALS, #GreysAnatomy, #InMemoriam

https://newsletter.tf/chyler-leigh-eric-dane-death-als-advocacy/

NewsletterTF 4d ago

Chyler Leigh recently spoke about Eric Dane's passing, remembering his strength in fighting ALS and his love for his daughters.

#EricDane, #ChylerLeigh, #ALS, #GreysAnatomy, #InMemoriam
https://newsletter.tf/chyler-leigh-eric-dane-death-als-advocacy/

Chyler Leigh Speaks About Eric Dane's Death and ALS Fight

Chyler Leigh shares memories of Eric Dane, focusing on his fatherhood and ALS advocacy after his recent passing.

NewsletterTF

Omroep West 6d ago

Pieter rent 75 kilometer voor ALS: 'Medicijn komt voor mijn vader te laat' #OmroepWest #Leiden #Als #Ultramarathon #75Kilometer #Hardlopen #Burcht

https://owst.nl/5100515/M

Pieter rent 75 kilometer voor ALS: 'Medicijn komt voor mijn vader te laat'

'Ik zet alles op alles om bij te dragen aan een oplossing, al weet ik dat een medicijn voor mijn vader te laat komt.' Met die motivatie rende Pieter Hoogstraten vrijdag maar liefst 75 kilometer rond de Burcht van Leiden. Met zijn sponsoractie haalde hij geld op voor onderzoek naar ALS, de ziekte waar zijn vader aan lijdt.

Omroep West

The vOICe vision BCI 🧠🇪🇺May 14

Implanted brain-computer interface functionality during nighttime in late-stage amyotrophic lateral sclerosis www.nature.com/articles/s41... "When applied to night data, daytime decoders caused unintentional BCI activations in 100% of nights." #ALS #BCI #NeuroTech

Implanted brain-computer inter...

Implanted brain-computer interface functionality during nighttime in late-stage amyotrophic lateral sclerosis - Scientific Reports

Brain-computer interfaces (BCIs) hold promise as assistive communication technology for people with severe paralysis. Although such BCIs should be available 24/7, feasibility of nocturnal BCI use has not been investigated. Here, we addressed this question using data from an electrocorticography-BCI user with amyotrophic lateral sclerosis. We investigated nocturnal dynamics of neural signal features used for BCI control. Additionally, we assessed nocturnal performance of a decoder trained on daytime data, by quantifying the number of unintentional BCI activations at night. Finally, we developed a nightmode functionality and assessed its performance. Mean and variance of low and high frequency band power were significantly higher at night than during the day. When applied to night data, daytime decoders caused unintentional BCI activations in 100% of nights (245 unintended click-commands and 13 unintended caregiver-calls per hour). The specifically developed nightmode functionality, however, functioned error-free in 79% of nights over a period of ± 1.5 years, allowing the user to reliably call the caregiver. Reliable nighttime use of a BCI requires strategies to adjust to circadian and sleep-related signal changes. This demonstration of a reliable nightmode and its long-term use by an individual with amyotrophic lateral sclerosis underscores the importance of 24/7 BCI reliability.

Nature

The vOICe vision BCI 🧠🇪🇺May 14

Implanted brain-computer interface functionality during nighttime in late-stage amyotrophic lateral sclerosis https://www.nature.com/articles/s41598-026-44228-7 "When applied to night data, daytime decoders caused unintentional BCI activations in 100% of nights." #ALS #BCI #NeuroTech

Implanted brain-computer interface functionality during nighttime in late-stage amyotrophic lateral sclerosis - Scientific Reports

Brain-computer interfaces (BCIs) hold promise as assistive communication technology for people with severe paralysis. Although such BCIs should be available 24/7, feasibility of nocturnal BCI use has not been investigated. Here, we addressed this question using data from an electrocorticography-BCI user with amyotrophic lateral sclerosis. We investigated nocturnal dynamics of neural signal features used for BCI control. Additionally, we assessed nocturnal performance of a decoder trained on daytime data, by quantifying the number of unintentional BCI activations at night. Finally, we developed a nightmode functionality and assessed its performance. Mean and variance of low and high frequency band power were significantly higher at night than during the day. When applied to night data, daytime decoders caused unintentional BCI activations in 100% of nights (245 unintended click-commands and 13 unintended caregiver-calls per hour). The specifically developed nightmode functionality, however, functioned error-free in 79% of nights over a period of ± 1.5 years, allowing the user to reliably call the caregiver. Reliable nighttime use of a BCI requires strategies to adjust to circadian and sleep-related signal changes. This demonstration of a reliable nightmode and its long-term use by an individual with amyotrophic lateral sclerosis underscores the importance of 24/7 BCI reliability.

Nature