During fly #metamorphosis, the #adipose tissue of the adult is assembled from proliferating #adipocyte precursors that spread from the ventral midline in a process that recapitulates embryonic #mesoderm migration @NeuroAlc @Tsinghua_Uni #PLOSBiology https://plos.io/3yZEnXv
FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila

This study shows that during fly metamorphosis, the adipose tissue of the adult is assembled from proliferating adipocyte precursors that spread from the ventral midline in a process that recapitulates embryonic mesoderm migration.

During fly #metamorphosis, the #adipose tissue of the adult is assembled from proliferating #adipocyte precursors that spread from the ventral midline in a process that recapitulates embryonic #mesoderm migration @NeuroAlc @Tsinghua_Uni #PLOSBiology https://plos.io/3yZEnXv
FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila

This study shows that during fly metamorphosis, the adipose tissue of the adult is assembled from proliferating adipocyte precursors that spread from the ventral midline in a process that recapitulates embryonic mesoderm migration.

During fly #metamorphosis, the #adipose tissue of the adult is assembled from proliferating #adipocyte precursors that spread from the ventral midline in a process that recapitulates embryonic #mesoderm migration @NeuroAlc @Tsinghua_Uni #PLOSBiology https://plos.io/3yZEnXv
FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila

This study shows that during fly metamorphosis, the adipose tissue of the adult is assembled from proliferating adipocyte precursors that spread from the ventral midline in a process that recapitulates embryonic mesoderm migration.

Single-cell imaging during #adipocyte differentiation reveals a control principle whereby #progenitor cells induced to differentiate can reach the desired distinct differentiated #CellFate despite the many alternative fates en route @TeruelLab #PLOSBiology https://plos.io/3Y38VTu
Early enforcement of cell identity by a functional component of the terminally differentiated state

How can progenitor cells attain a distinct differentiated cell identity, given the fluctuating signaling environment and redundancy of critical transcription factors? This study identifies a control principle whereby progenitor cells induced to differentiate can reach the desired distinct differentiated cell fate despite the possibility of many alternative fates en route.

Single-cell imaging during #adipocyte differentiation reveals a control principle whereby #progenitor cells induced to differentiate can reach the desired distinct differentiated #CellFate despite the many alternative fates en route @TeruelLab #PLOSBiology https://plos.io/3Y38VTu
Early enforcement of cell identity by a functional component of the terminally differentiated state

How can progenitor cells attain a distinct differentiated cell identity, given the fluctuating signaling environment and redundancy of critical transcription factors? This study identifies a control principle whereby progenitor cells induced to differentiate can reach the desired distinct differentiated cell fate despite the possibility of many alternative fates en route.

Single-cell imaging during #adipocyte differentiation reveals a control principle whereby #progenitor cells induced to differentiate can reach the desired distinct differentiated #CellFate despite the many alternative fates en route @TeruelLab #PLOSBiology https://plos.io/3Y38VTu
Early enforcement of cell identity by a functional component of the terminally differentiated state

How can progenitor cells attain a distinct differentiated cell identity, given the fluctuating signaling environment and redundancy of critical transcription factors? This study identifies a control principle whereby progenitor cells induced to differentiate can reach the desired distinct differentiated cell fate despite the possibility of many alternative fates en route.

Cancer du sein : les cellules tumorales transformées en graisse

Chez la souris, des chercheurs de l’université de Bâle ont transformé des cellules cancéreuses du sein en cellules de graisse, par un processus de « transdifférenciation ». Cette méthode expérimentale empêche les métastases et propose une nouvelle stratégie de lutte contre le cancer.

https://www.futura-sciences.com/sante/actualites/cancer-sein-cancer-sein-cellules-tumorales-transformees-graisse-74686/

#cancer_du_sein #transdifférenciation #métastase #dédifférenciation #cellule_dédifférenciée #cancer #bloquer_la_propagation_des_métastases #cellule_adipeuse #adipocyte #tumeur_mammaire

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Cancer du sein : les cellules tumorales transformées en graisse

Chez la souris, des chercheurs de l’université de Bâle ont transformé des cellules cancéreuses du sein en cellules de graisse, par un processus de « transdifférenciation ». Cette méthode...