A bit of a run around, extra blood tests, lip op/biopsy, MRI and shingles vax still to do, but rheumy intends to take me off #Adalimumab (Humira) next quarter as it has stopped working. Apparently this is common with biologics - develop antibodies to it, CRP goes up, more bits get swollen and hurt for longer periods, joints worsen.

Extra tests to see if we can pinpoint the #spondyloarthritis flavour it actually is, and then likely an IL-12 blocker. Fewer injections (yay!), but quite an increased shingles risk, thus that vax requirement.

#ChronicIllness #spoonies

New instructions from the rheumy, if sick (infection), don’t take #adalimumab. Wait until well.
Bit hard to guess that if you’re already incubating, but are not symptomatic.though. I’ll delay the next one to help recovery - don’t want any relapse.

Good note - doc wrangled authorisation from the health insurer for the expensive Pfizer paxlovid.

Before mum passed, she asked why my adalimumab syringe was so much bigger, with a lot more liquid than her multi-use insulin. And why I pushed it in so slowly (the auto-pen type is too hard for my hands!)

Today is dose-day, so it came to mind, and I went looking - how much less liquid is in a dose of insulin? Or a vaccine for that matter?

Very hard to find a straight answer - in units or dosage mg only.

Mine is 40mg in .8ml of liquid … it feels a lot.

#adalimumab

Fungal allergies are not well studied - I found only one* talking about the impact of powdery mildew on humans.

Seeing as this type of mold aggravates TNF-alpha to cause an inflammation response in the respiratory system, I’m sure that this must interact with adalimumab (Humira) as the medication switches this cytokine off.

*https://pubmed.ncbi.nlm.nih.gov/37933334/

#adalimumab #allergies #ChronicIllness

Fingernail sides are still terribly painful a day later. Yesterday was unbearable. When something says pain-free (Schmerzlos), don’t believe it.

But, it seems to have killed more of the periunguals than all other treatments*.

Found a new product - a combo of lactic, oxalic, acetic and nitric acids plus copper and zinc salts - less than a drop from a glass ampule applied via the finest of glass capillary tubes. Felt very laboratory chemisty.

Have to see how they are after a week or so, but hopeful.

* am allergic to salicylic acid, and immune suppressed, thus the stubbornness of the virus.

#ChronicIllness #Adalimumab

I'm now keeping an eye on: The SmPC for Hyrimoz 40 mg solution for injection in pre-filled pen (Low concentration)

<f0><9f><8f><ad>Sandoz Limited

<f0><9f><92><8a><f0><9f><92><89> #adalimumab.

I will let you know if it changes.

<f0><9f><8c><90> https://www.medicines.org.uk/emc/product/9549/smpc

I'm now keeping an eye on: The SmPC for Hyrimoz 40mg solution for injection in pre-filled pen (High concentration)

<f0><9f><8f><ad>Sandoz Limited

<f0><9f><92><8a><f0><9f><92><89> #adalimumab.

I will let you know if it changes.

<f0><9f><8c><90> https://www.medicines.org.uk/emc/product/15630/smpc