The Tricarboxylic Acid Cycle

#AcetylCoA, #CitricAcidCycle, #Glycolysis, #KrebsCycle, #TCACycle #Biochemistry There are several metabolic pathways have been identified, those are used to liberate energy from food components. In the glycolytic…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/04/27/the-tricarboxylic-acid-cycle/

The Tricarboxylic Acid Cycle

#AcetylCoA, #CitricAcidCycle, #Glycolysis, #KrebsCycle, #TCACycle #Biochemistry There are several metabolic pathways have been identified, those are used to liberate energy from food components. In…

Medical Microbiology & RDT Labs
Canonical #glycolysis converts glucose into 2x #acetylCoA via eleven biochemical reactions. This study repurposes #phosphoketolase to construct an artificial three-reaction pathway with a theoretical 100% yield of acetyl-CoA from any sugar. #SynBio #PLOSBiology https://plos.io/48sKTH0
Construction of an artificial phosphoketolase pathway that efficiently catabolizes multiple carbon sources to acetyl-CoA

The canonical glycolysis pathway converts glucose into two molecules of acetyl-CoA via a cascade of eleven biochemical reactions. This study repurposes phosphoketolase to construct an artificial pathway which comprises only three reactions and could theoretically achieve a 100% carbon yield of acetyl-CoA from any sugar.

https://www.cell.com/heliyon/fulltext/S2405-8440(23)02488-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS240584402302488X%3Fshowall%3Dtrue

"To examine whether #muscle contraction changes the distribution of #carnitine and its derivatives, unilateral in situ muscle contraction was performed; 60 min muscle contraction showed increased d3-carnitine and its derivative d3-acetylcarnitine in the muscle, indicating that carnitine uptake in cells is promptly converted to acetylcarnitine, consequently, buffering accumulated acetyl-CoA."

#acetylCoA #skeletalMuscle #metabolism #catabolism