The crystal structure of the Mu8.1 conotoxin at 1.67 Å resolution reveals a network of water molecules that surround a potential functional residue, Lys55, with an unusually low pKa
@DTUtweet @koebenhavns_uni @IUCr #Conotoxins #ZnBinding #Toxins https://doi.org/10.1107/S2053230X23007070
@DTUtweet @koebenhavns_uni @IUCr #Conotoxins #ZnBinding #Toxins https://doi.org/10.1107/S2053230X23007070
High-resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus
The crystal structure of the Mu8.1 conotoxin was determined in the high-symmetry space group I4122 at 1.67 Å resolution. This crystal structure reveals a surface-exposed Zn2+-binding site and establishes a hydrogen-bonding network around Lys55 buried at the dimer interface.
