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Scy_25 Oct 23

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CellBioNews May 25, 2023

How the #epigenetic landscape modulates pioneer #transcription factor binding.

#nucleosomes #Yamanaka #histones

https://phys.org/news/2023-05-epigenetic-landscape-modulates-transcription-factor.html

How the epigenetic landscape modulates pioneer transcription factor binding

Like thread tightly wrapped around a spool, DNA is wrapped around histones and packaged into structures called nucleosomes. Scientists at St. Jude Children's Research Hospital are exploring how a type of transcription factor called a pioneer transcription factor accesses DNA even when it is tightly wound. Their work revealed how the epigenetic landscape influences transcription factor binding.

Phys.org