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RT @BrownJHM
Patient w/fever, chills & dyspnea. Diagnosis, next steps? (Image: Kauveri hospital) #medtwitter
https://twitter.com/BrownJHM/status/1650442992396689409
Clinical evidence of vascular dysfunction and hypercoagulability as well as pulmonary vascular damage and microthrombosis are frequently reported in severe cases of human COVID-19 disease. Syrian golden hamsters recapitulate histopathologic pulmonary vascular lesions reported in COVID-19 patients. Here, special staining techniques and transmission electron microscopy further define vascular pathologies in a Syrian golden hamster model of human COVID-19 disease. The results show that regions of active pulmonary inflammation in SARS-CoV-2 infection are characterized by ultrastructural evidence of endothelial damage with platelet marginalization and both perivascular and subendothelial macrophage infiltration.
Background and Purpose: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with an increased rate of cerebrovascular events including ischemic stroke and intracerebr