Diabetic macular edema
Diabetic retinopathy is characterized by increased vascular permeability, leading to leakage of blood and fluid into the retina. Fluorescein angiography (FA) is used to assess this permeability, revealing areas of leakage, microaneurysms, and also neovascularization. FA helps in evaluating the extent of retinal damage and guiding treatment decisions. #DiabeticRetinopathy #VascularPermeability #FluoresceinAngiography #FA #RetinaImaging #retina…
#LaminarShear pushes VE-PTP (How?🤓) to downstream pole of #EndothelialCell, followed by endocytosis->⏫p-Tie2
Potentially explain how #DisturbedFlow⏫#VascularPermeability & #Atherosclerosis
Inhibition of VE-PTP by AKB-9785 fortifies #EndothelialBarrier & reduces Atheromas at atheroprone regions (aortic arch inner curvature, arch+intercostal bifurcations)🐭
Nice comparison of anti-leakage strategies
VE-PTP inhibition
Angpt1 activation of Tie2
Angpt2 inhibition
Dr. Donald McDonald & Dietmar Vestweber labs EMBO Mol Med 2023
https://www.embopress.org/doi/
Ricardo Leitão Guerra
Hao Yin