Great talk by Satpal Virdee at #Biochemistry2026. He talked about methods to identify and characterize ubiquitin(-like) E1 and E3 enzymes by crosslinking to tools based on (Ubl-modified) E2s.
https://pubs.acs.org/doi/10.1021/acschembio.5b00118
https://www.nature.com/articles/nchembio.2045
#Biochemistry #ChemBio #ubiquitin #tools #Chemistry
CC: @gdch, @GDCh_BioChem
The second day of #Biochemistry2026 gets on the way with an exciting talk by Satpal Virdee. "Next-generation Activity-Based Probes for Ubiquitin and Ubiquitin-like E3 Ligases".
https://www.nature.com/articles/nchembio.2045
#ChemBio #Biochemistry #Chemistry #ubiquitin #TPD #degradation
CC: @gdch
`We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan.`
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00598-1
#biomarker #lifespan #aging #biology #ubiquitin #apoptosis #neuron #neuronal #neuroscience #neurodegeneration #disease #brain
Great talk by Martijn Verdoes at the #iCNS meeting. He talked about the many exciting research lines of his group including the work on using the ubiquitination machinery to make highly defined, site-specifically modified antibodies.
https://www.nature.com/articles/s41551-025-01368-x
#Chemistry #ChemBio #antibodies #ubiquitin
Great talk by Bianca van Tol at #NWOCHAINS. She talked about the development of neutron-encoded ubiquitins and diubiquitins to study the linkage selectivity of E2 enzymes, E3 ligases and deubiquitinating enzymes.
https://www.nature.com/articles/s41467-023-37363-6
#Chemistry #ChemBio #Ubiquitin
🧬 Ubiquitin Precursor: A Key to Healthy Aging?
Researchers from the #UniCologne and the Heinrich-Heine-Universität Düsseldorf have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging. This discovery opens up potentially new perspectives for the treatment of cancer and age-related diseases.
Read more ▶️ https://uni.koeln/BLXJA
📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373
#uniköln #unicologne #Research #Ubiquitin #Cancer #Aging #Health #proteostasis
🧬 Ubiquitin-Vorläufer: Ein Schlüssel zum gesunden Altern?
Forscher*innen der #UniKöln und der @HHU haben eine neue Form des Proteins Ubiquitin identifiziert, die für die Proteostase und gesundes Altern verantwortlich ist. Diese Entdeckung eröffnet potenziell neue Perspektiven für die Behandlung von Krebs und altersbedingten Krankheiten.
Mehr dazu ▶️ https://uni.koeln/AALLM
📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373
#uniköln #unicologne #Forschung #Krebs #Altern #Gesundheit #Ubiquitin
Abstract Human exposure to radiation, such as cosmic and earth background radiation, industrial background radiation, as well as radiation cause by various human activities is know to trigger various intra and extra-cellular responses. It is also known that the radiation response and sensitivity is age-dependent. Ubiquitin conjugates in murine blood serum were analized under normal and pathological conditions caused by irradiation across different age groups. Nonlinear white mice Mus Musculus were used for tests. The source of radiation was 137Cs with dose rate 1Gy/min, due exposure 5 min (LD50 5Gy) executed using the “GUPOS-3M” gamma facility. Using immunoblotting for measurement data was statistically analyzed to unveil changes in ubiquitin conjugate levels following ionizing radiation and intraperitoneal ubiquitin administration. Age-related variability in ubiquitin conjugates levels is identified, shedding light on ubiquitin injection role in modulating radiation responses across age groups. These findings hold implications for cellular biology and clinical radiation therapy, offering hope for future therapeutic interventions and enhanced radiation therapy outcomes.
Stephan Hacker
GDCh Division of Biochemistry
katch wreck
Stephan Hacker
Universität zu Köln
Cytology and Genetics